Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 7843290..7843861 Replicon chromosome
Accession NZ_CP094526
Organism Bradyrhizobium sp. ISRA464

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MTX19_RS36335 Protein ID WP_280981487.1
Coordinates 7843511..7843861 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MTX19_RS36330 Protein ID WP_213290777.1
Coordinates 7843290..7843514 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX19_RS36310 (MTX19_36130) 7839686..7841155 - 1470 WP_280985725.1 TM0106 family RecB-like putative nuclease -
MTX19_RS36315 (MTX19_36135) 7841312..7841467 - 156 WP_280978692.1 hypothetical protein -
MTX19_RS36320 (MTX19_36140) 7841464..7842686 - 1223 Protein_7217 IS701 family transposase -
MTX19_RS36325 (MTX19_36145) 7842732..7843133 - 402 Protein_7218 IS5 family transposase -
MTX19_RS36330 (MTX19_36150) 7843290..7843514 + 225 WP_213290777.1 antitoxin MazE family protein Antitoxin
MTX19_RS36335 (MTX19_36155) 7843511..7843861 + 351 WP_280981487.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MTX19_RS36340 (MTX19_36160) 7843953..7844321 - 369 Protein_7221 IS5 family transposase -
MTX19_RS36345 (MTX19_36165) 7844415..7845065 - 651 WP_280981488.1 TetR/AcrR family transcriptional regulator -
MTX19_RS36350 (MTX19_36170) 7845277..7846170 + 894 WP_280981489.1 NAD(P)/FAD-dependent oxidoreductase -
MTX19_RS36355 (MTX19_36175) 7846208..7846963 + 756 WP_280981490.1 alpha/beta fold hydrolase -
MTX19_RS36360 (MTX19_36180) 7847120..7848046 + 927 WP_280981491.1 NmrA family NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(12-74)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13007.16 Da        Isoelectric Point: 9.8954

>T239943 WP_280981487.1 NZ_CP094526:7843511-7843861 [Bradyrhizobium sp. ISRA464]
MRRGEIWTVAGGKDYADKPRPVVIVQDDRFDATDTITICAFTTDPTDAPLFRLIIEPNERNGLLSTCRLMVDKITTVPKV
KVGRRVGRLDDENMVRLNQAMMVFLGMAVSPRGGRK

Download         Length: 351 bp

>T239943 NZ_LS483410:2330821-2331117 [Legionella pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8451.47 Da        Isoelectric Point: 10.9254

>AT239943 WP_213290777.1 NZ_CP094526:7843290-7843514 [Bradyrhizobium sp. ISRA464]
MATASRPKPGRMKVREHRERLRAQGLRPIQIWVPDVRSSSFRKQAHRQSLAVAASSHARDDQAFIDDVSDLDDE

Download         Length: 225 bp

>AT239943 NZ_LS483410:2330577-2330831 [Legionella pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References