Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4702426..4703047 Replicon chromosome
Accession NZ_CP094526
Organism Bradyrhizobium sp. ISRA464

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX19_RS22200 Protein ID WP_280979299.1
Coordinates 4702646..4703047 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX19_RS22195 Protein ID WP_280979298.1
Coordinates 4702426..4702656 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX19_RS22170 (MTX19_22050) 4697928..4698170 - 243 WP_280979293.1 hypothetical protein -
MTX19_RS22175 (MTX19_22055) 4698191..4698967 - 777 WP_280979294.1 DUF899 domain-containing protein -
MTX19_RS22180 (MTX19_22060) 4699062..4700282 + 1221 WP_280979295.1 helix-turn-helix domain-containing protein -
MTX19_RS22185 (MTX19_22065) 4700316..4700960 + 645 WP_280979296.1 glutamine cyclotransferase -
MTX19_RS22190 (MTX19_22070) 4701014..4702228 - 1215 WP_280979297.1 MFS transporter -
MTX19_RS22195 (MTX19_22075) 4702426..4702656 + 231 WP_280979298.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX19_RS22200 (MTX19_22080) 4702646..4703047 + 402 WP_280979299.1 PIN domain-containing protein Toxin
MTX19_RS22205 (MTX19_22085) 4703071..4703188 + 118 Protein_4400 cupin domain-containing protein -
MTX19_RS22210 (MTX19_22090) 4703272..4704789 - 1518 WP_280979300.1 MFS transporter -
MTX19_RS22215 (MTX19_22095) 4704995..4705933 + 939 WP_280979301.1 LysR family transcriptional regulator -
MTX19_RS22220 (MTX19_22100) 4705960..4706871 - 912 WP_280979302.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14643.74 Da        Isoelectric Point: 6.0749

>T239942 WP_280979299.1 NZ_CP094526:4702646-4703047 [Bradyrhizobium sp. ISRA464]
MPGDFFDTNVLVYLASGDPLKADRAEAVIARGGAISVQVLNEVTNVARRKMRMSWTETRAFLTILRNLLTVHPLTLESHD
TGLDLAERYSLSTFDAMIAGSALHAGCDRLWSEDMQHGLVLDGSLRIANPFRA

Download         Length: 402 bp

>T239942 NZ_LS483410:c71312-70008 [Legionella pneumophila]
ATGGTAATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGAGCTTACCCAGGATAATGCAGGTGGTTTGAG
TTTTTCCTACGTTGCTGACTGGATTTCCAAACCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAGTAAATCAAAAAT
TTTCAGGAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGAATTCAAGCTCGT
TTTCAGGCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCAGTGATTGTGTTGGTGCAATACAAATTGTTGA
ACGTATTCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTT
ACCAAACCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCT
TTTCTATATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATA
TTTACCACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTT
TAGATGTTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAAGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGT
CGAGATAACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCA
GTCAGATGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGACAGAGATGAAT
TTTTCAGAGCACAAGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCA
CAAGGCGGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATCCTATCGTGGAACAAAAACAGCTATCCTTTAA
GAAATTGAAAATGGCAATGGCTTTATATGGTAAAAATATTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTG
AAACAGCAAAATACGTTAAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCT
ATCGATGAGGTCTCAAGACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTT
TAAGGAGCGAATGATATCCACATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8615.87 Da        Isoelectric Point: 10.1733

>AT239942 WP_280979298.1 NZ_CP094526:4702426-4702656 [Bradyrhizobium sp. ISRA464]
MQVAKWGNSLAIRLPASVVEALKLKEGDEIEIHVADERNFGVARKPGREELLARLRAFRGRLPADFKFDRDEANAR

Download         Length: 231 bp

>AT239942 NZ_LS483410:c71545-71306 [Legionella pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCCGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGAGATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References