Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3027457..3028082 Replicon chromosome
Accession NZ_CP094526
Organism Bradyrhizobium sp. ISRA464

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MTX19_RS13950 Protein ID WP_280984089.1
Coordinates 3027894..3028082 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MTX19_RS13945 Protein ID WP_280984088.1
Coordinates 3027457..3027849 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX19_RS13920 (MTX19_13855) 3023250..3024014 - 765 WP_280984085.1 flagellar basal-body rod protein FlgF -
MTX19_RS13925 (MTX19_13860) 3024396..3024884 + 489 WP_280984086.1 flagellar basal body-associated protein FliL -
MTX19_RS13930 (MTX19_13865) 3024903..3026105 + 1203 WP_280976975.1 flagellar motor switch protein FliM -
MTX19_RS13935 (MTX19_13870) 3026102..3026569 + 468 WP_280976976.1 DUF6468 domain-containing protein -
MTX19_RS13940 (MTX19_13875) 3026566..3027369 + 804 WP_280984087.1 flagellar protein FlbB -
MTX19_RS13945 (MTX19_13880) 3027457..3027849 - 393 WP_280984088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MTX19_RS13950 (MTX19_13885) 3027894..3028082 - 189 WP_280984089.1 type II toxin-antitoxin system HicA family toxin Toxin
MTX19_RS13955 (MTX19_13890) 3028327..3032109 + 3783 WP_280984090.1 tetratricopeptide repeat protein -
MTX19_RS13960 (MTX19_13895) 3032738..3032971 - 234 WP_280984091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6974.20 Da        Isoelectric Point: 11.5372

>T239941 WP_280984089.1 NZ_CP094526:c3028082-3027894 [Bradyrhizobium sp. ISRA464]
MRSTDIIKALLADGWRQVTQKGSHVQFKHPTKPGRVTVPHPKRDIPVGTFKSIEKQSGLKLK

Download         Length: 189 bp

>T239941 NZ_LS483409:c1839094-1838762 [Streptococcus gallolyticus]
ATGGATTATAAGAAGTACAAGCTTATCTATTCTCAAAGGGGCATTGACACGCTTGATGATATTTATCATTATATTGCTAA
TGAAATAGGCTCAACAATTAACGCTAAAAAGAAAATTGCAAGTATTAGGAAAGATTTACAACGCTTGGAGTTTTTTCCAG
AGGGTGGTTTTGATGCTGATGAAAAATTTGGAAAGTGTCTGGATCCCAAGTATAAAACAAGAGGTTTAACGTTGAGTAAG
GACTATATTGCCTTGTATAACATTTTGGAAAATGAGGTTCGTATAGCATATTTGTTACCTACTCGCAGTGACTATATGGA
TTTATTTAGATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13869.52 Da        Isoelectric Point: 4.1632

>AT239941 WP_280984088.1 NZ_CP094526:c3027849-3027457 [Bradyrhizobium sp. ISRA464]
MRHYIALIHKDADSDYGVSFPDLPGVITAGTDLDDARTMAAEALALHLEGLAEDGEAVPEPSSLEEIMADVENRDGVAVL
IPAPSEGVKSVRVNITLPSDILNEIDRRAEQEGFTRSGFLAQAARKALTA

Download         Length: 393 bp

>AT239941 NZ_LS483409:c1839368-1839084 [Streptococcus gallolyticus]
ATGGCTTTAGCTTATGATAAAAGTTACAATTTAAGAACTTATCAAAAAATTTATAACCAAGCAGAAAAAGTATTTAAGGA
AAATAATTTAAATACCGCTCAGGCTTTAAATTTATTTCTAAAAAATGTTGCTGAAACAGGTCAACTTAATTTGAAAACAG
AAGAAGAACTTAAAAGAGAAAAGTTGTTTAAAAATCTTCAAGCAGAGATTCAACAAAGTTATGCTGAATTTGATGAAGGG
AAATTTTATACTGATGAGGATTTGGTAGAACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References