Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2977068..2977702 Replicon chromosome
Accession NZ_CP094526
Organism Bradyrhizobium sp. ISRA464

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX19_RS13645 Protein ID WP_280984041.1
Coordinates 2977068..2977469 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX19_RS13650 Protein ID WP_280984042.1
Coordinates 2977466..2977702 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX19_RS13625 (MTX19_13560) 2974701..2975009 + 309 Protein_2703 hypothetical protein -
MTX19_RS13630 2975253..2975495 + 243 Protein_2704 hypothetical protein -
MTX19_RS13635 (MTX19_13570) 2975556..2976119 + 564 Protein_2705 multicopper oxidase domain-containing protein -
MTX19_RS13640 (MTX19_13575) 2976100..2976402 + 303 WP_280984040.1 copper-binding protein -
MTX19_RS13645 (MTX19_13580) 2977068..2977469 - 402 WP_280984041.1 type II toxin-antitoxin system VapC family toxin Toxin
MTX19_RS13650 (MTX19_13585) 2977466..2977702 - 237 WP_280984042.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX19_RS13655 (MTX19_13590) 2978164..2978340 + 177 Protein_2709 integrase core domain-containing protein -
MTX19_RS13660 (MTX19_13595) 2978500..2980052 + 1553 Protein_2710 ISL3 family transposase -
MTX19_RS13665 (MTX19_13600) 2980104..2980223 + 120 Protein_2711 SOS response transcriptional repressor -
MTX19_RS13670 (MTX19_13605) 2980536..2980997 + 462 WP_280984043.1 GNAT family N-acetyltransferase -
MTX19_RS13675 (MTX19_13610) 2981679..2981960 + 282 WP_280984044.1 tRNA 5-methylaminomethyl-2-thiouridine synthase -
MTX19_RS13680 (MTX19_13615) 2982209..2982589 - 381 WP_280984782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14219.39 Da        Isoelectric Point: 6.9532

>T239940 WP_280984041.1 NZ_CP094526:c2977469-2977068 [Bradyrhizobium sp. ISRA464]
VTRYLLDTNIISDLVRNPQGKVAKRIAKVGEANVCTSIIVASELRYGCAKAGSPRLTKAVEEILGEIPVLPFDVPADAEY
GVVRSELEAAGKPIGSNDLLIAAHASALSMTIVTANTDEFKRARGLKVTNWLD

Download         Length: 402 bp

>T239940 NZ_LS483409:c1663099-1662911 [Streptococcus gallolyticus]
GTGCCGCTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACGATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9076.58 Da        Isoelectric Point: 10.4369

>AT239940 WP_280984042.1 NZ_CP094526:c2977702-2977466 [Bradyrhizobium sp. ISRA464]
MTQRRHVRLFRNGRNQAVRIPVEFEMPGDEATMFRDGDRLVIEPLRKRGLLALLKTMTPVAEHFPEIDDPAPKPERVL

Download         Length: 237 bp

>AT239940 NZ_LS483409:c1662899-1662519 [Streptococcus gallolyticus]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGATGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATTTAGATG
AAGGGTTAGAGCTTCCAAAAGTTGTTGATATGAGTGAATTATCAGTTGAAGATGGTTTTATTACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAACGTTACGGTTCCAGAATGGTTAGTCAGATTAGCTGATAG
GGAACATGTTAATTATTCAGAAGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References