Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 8304655..8305226 Replicon chromosome
Accession NZ_CP094525
Organism Bradyrhizobium sp. ISRA463

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MTX22_RS38985 Protein ID WP_280981487.1
Coordinates 8304876..8305226 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MTX22_RS38980 Protein ID WP_213290777.1
Coordinates 8304655..8304879 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX22_RS38960 (MTX22_38705) 8301052..8302581 - 1530 WP_280984993.1 TM0106 family RecB-like putative nuclease -
MTX22_RS38965 (MTX22_38710) 8302677..8302832 - 156 WP_280978692.1 hypothetical protein -
MTX22_RS38970 (MTX22_38715) 8302829..8304051 - 1223 Protein_7740 IS701 family transposase -
MTX22_RS38975 (MTX22_38720) 8304097..8304498 - 402 Protein_7741 IS5 family transposase -
MTX22_RS38980 (MTX22_38725) 8304655..8304879 + 225 WP_213290777.1 antitoxin MazE family protein Antitoxin
MTX22_RS38985 (MTX22_38730) 8304876..8305226 + 351 WP_280981487.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MTX22_RS38990 (MTX22_38735) 8305318..8305686 - 369 Protein_7744 IS5 family transposase -
MTX22_RS38995 (MTX22_38740) 8305780..8306430 - 651 WP_280981488.1 TetR/AcrR family transcriptional regulator -
MTX22_RS39000 (MTX22_38745) 8306642..8307535 + 894 WP_280981489.1 NAD(P)/FAD-dependent oxidoreductase -
MTX22_RS39005 (MTX22_38750) 8307573..8308328 + 756 WP_280981490.1 alpha/beta fold hydrolase -
MTX22_RS39010 (MTX22_38755) 8308485..8309411 + 927 WP_280981491.1 NmrA family NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(12-74)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13007.16 Da        Isoelectric Point: 9.8954

>T239938 WP_280981487.1 NZ_CP094525:8304876-8305226 [Bradyrhizobium sp. ISRA463]
MRRGEIWTVAGGKDYADKPRPVVIVQDDRFDATDTITICAFTTDPTDAPLFRLIIEPNERNGLLSTCRLMVDKITTVPKV
KVGRRVGRLDDENMVRLNQAMMVFLGMAVSPRGGRK

Download         Length: 351 bp

>T239938 NZ_LS483409:710925-711194 [Streptococcus gallolyticus]
ATGACTTATAGATTGGTTGTTAGTGACAAGGTCAAGAAACAACTAAAGAAAATGGATAAGCATGTAAGGCTTATGCTTGC
TAAAGACATGAAGAAACACCTTGATGGTTTAGAGAACCCTAGACAAATTGGAAAAGCACTAATAGGTCAATTCAAAGGCC
TATGGCGTTACCGAATAGGAAATTATAGAGTTATTTGTGATATTATGGACGATGAATTAGTTATTCTTGCTATTGAAATC
GGACATAGAAAAGATATTTATAAAAACTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8451.47 Da        Isoelectric Point: 10.9254

>AT239938 WP_213290777.1 NZ_CP094525:8304655-8304879 [Bradyrhizobium sp. ISRA463]
MATASRPKPGRMKVREHRERLRAQGLRPIQIWVPDVRSSSFRKQAHRQSLAVAASSHARDDQAFIDDVSDLDDE

Download         Length: 225 bp

>AT239938 NZ_LS483409:710708-710935 [Streptococcus gallolyticus]
ATGTCAATCGTATCACTTAGACTAAATGAAAAAGAAGAAGAACTTTTTAGAAGTTATTCTATCCATACAGGAAAGACATT
ATCAGAGTTGTTTAAAACAGCTTTAGCTGAACAAATTGAAGACCAATTAGATTATGAAACAGGCATTAAAGCATTGAAAG
AATTCAAAAAGAATCCTGTTACTCACTCTATTGATGATATTATTGAGGAGTTTGAAAATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References