Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 5162289..5162910 Replicon chromosome
Accession NZ_CP094525
Organism Bradyrhizobium sp. ISRA463

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX22_RS24570 Protein ID WP_280979299.1
Coordinates 5162509..5162910 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX22_RS24565 Protein ID WP_280979298.1
Coordinates 5162289..5162519 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX22_RS24540 (MTX22_24385) 5157791..5158033 - 243 WP_280979293.1 hypothetical protein -
MTX22_RS24545 (MTX22_24390) 5158054..5158830 - 777 WP_280979294.1 DUF899 domain-containing protein -
MTX22_RS24550 (MTX22_24395) 5158925..5160145 + 1221 WP_280979295.1 helix-turn-helix domain-containing protein -
MTX22_RS24555 (MTX22_24400) 5160179..5160823 + 645 WP_280979296.1 glutamine cyclotransferase -
MTX22_RS24560 (MTX22_24405) 5160877..5162091 - 1215 WP_280979297.1 MFS transporter -
MTX22_RS24565 (MTX22_24410) 5162289..5162519 + 231 WP_280979298.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX22_RS24570 (MTX22_24415) 5162509..5162910 + 402 WP_280979299.1 PIN domain-containing protein Toxin
MTX22_RS24575 (MTX22_24420) 5162934..5163051 + 118 Protein_4867 cupin domain-containing protein -
MTX22_RS24580 (MTX22_24425) 5163135..5164652 - 1518 WP_280979300.1 MFS transporter -
MTX22_RS24585 (MTX22_24430) 5164858..5165796 + 939 WP_280979301.1 LysR family transcriptional regulator -
MTX22_RS24590 (MTX22_24435) 5165823..5166734 - 912 WP_280979302.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14643.74 Da        Isoelectric Point: 6.0749

>T239937 WP_280979299.1 NZ_CP094525:5162509-5162910 [Bradyrhizobium sp. ISRA463]
MPGDFFDTNVLVYLASGDPLKADRAEAVIARGGAISVQVLNEVTNVARRKMRMSWTETRAFLTILRNLLTVHPLTLESHD
TGLDLAERYSLSTFDAMIAGSALHAGCDRLWSEDMQHGLVLDGSLRIANPFRA

Download         Length: 402 bp

>T239937 NZ_LS483409:c277468-277190 [Streptococcus gallolyticus]
ATGTACCAAGTTAAGTTTACCTCTGCTTTTAAAAAGAGCTATAAACGAATTAAAAAGCGAGGCTTAGAGATGGCACTCTT
AGATGAAGTGATTGAAAAACTTCGTTTAGGTCAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCATATTAAACCAGATTGGCTTTTGATTTATCTGATTGAAGAGGATATTTTGACCCTAACGTTA
GCCGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8615.87 Da        Isoelectric Point: 10.1733

>AT239937 WP_280979298.1 NZ_CP094525:5162289-5162519 [Bradyrhizobium sp. ISRA463]
MQVAKWGNSLAIRLPASVVEALKLKEGDEIEIHVADERNFGVARKPGREELLARLRAFRGRLPADFKFDRDEANAR

Download         Length: 231 bp

>AT239937 NZ_LS483409:c277741-277469 [Streptococcus gallolyticus]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCAGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTCCCCA
ATTATAGTCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGACGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References