Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3487482..3488107 Replicon chromosome
Accession NZ_CP094525
Organism Bradyrhizobium sp. ISRA463

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MTX22_RS16255 Protein ID WP_280984089.1
Coordinates 3487919..3488107 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MTX22_RS16250 Protein ID WP_280984088.1
Coordinates 3487482..3487874 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX22_RS16225 (MTX22_16130) 3483275..3484039 - 765 WP_280984085.1 flagellar basal-body rod protein FlgF -
MTX22_RS16230 (MTX22_16135) 3484421..3484909 + 489 WP_280984086.1 flagellar basal body-associated protein FliL -
MTX22_RS16235 (MTX22_16140) 3484928..3486130 + 1203 WP_280976975.1 flagellar motor switch protein FliM -
MTX22_RS16240 (MTX22_16145) 3486127..3486594 + 468 WP_280976976.1 DUF6468 domain-containing protein -
MTX22_RS16245 (MTX22_16150) 3486591..3487394 + 804 WP_280984087.1 flagellar protein FlbB -
MTX22_RS16250 (MTX22_16155) 3487482..3487874 - 393 WP_280984088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MTX22_RS16255 (MTX22_16160) 3487919..3488107 - 189 WP_280984089.1 type II toxin-antitoxin system HicA family toxin Toxin
MTX22_RS16260 (MTX22_16165) 3488352..3492134 + 3783 WP_280984090.1 tetratricopeptide repeat protein -
MTX22_RS16265 (MTX22_16170) 3492763..3492996 - 234 WP_280984091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6974.20 Da        Isoelectric Point: 11.5372

>T239936 WP_280984089.1 NZ_CP094525:c3488107-3487919 [Bradyrhizobium sp. ISRA463]
MRSTDIIKALLADGWRQVTQKGSHVQFKHPTKPGRVTVPHPKRDIPVGTFKSIEKQSGLKLK

Download         Length: 189 bp

>T239936 NZ_LS483409:c273551-273297 [Streptococcus gallolyticus]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTTAAACGTATCAA
TCGTTTAATTGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATACCGTTATTCTGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATATGGTGGAAGAAGATGAAATTTATTTCTTATCCTTTCGA
GACCATTATAAATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13869.52 Da        Isoelectric Point: 4.1632

>AT239936 WP_280984088.1 NZ_CP094525:c3487874-3487482 [Bradyrhizobium sp. ISRA463]
MRHYIALIHKDADSDYGVSFPDLPGVITAGTDLDDARTMAAEALALHLEGLAEDGEAVPEPSSLEEIMADVENRDGVAVL
IPAPSEGVKSVRVNITLPSDILNEIDRRAEQEGFTRSGFLAQAARKALTA

Download         Length: 393 bp

>AT239936 NZ_LS483409:c273810-273544 [Streptococcus gallolyticus]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAGAATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACTATCC
GCCTAATGAATAACGATTATCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAGTCATTCAACGC
CCATTATTAGAGGTGAAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References