Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3437095..3437729 Replicon chromosome
Accession NZ_CP094525
Organism Bradyrhizobium sp. ISRA463

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX22_RS15940 Protein ID WP_280984041.1
Coordinates 3437095..3437496 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX22_RS15945 Protein ID WP_280984042.1
Coordinates 3437493..3437729 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX22_RS15920 (MTX22_15825) 3434728..3435036 + 309 Protein_3155 hypothetical protein -
MTX22_RS15925 3435280..3435522 + 243 Protein_3156 hypothetical protein -
MTX22_RS15930 (MTX22_15835) 3435583..3436146 + 564 Protein_3157 multicopper oxidase domain-containing protein -
MTX22_RS15935 (MTX22_15840) 3436127..3436429 + 303 WP_280984040.1 copper-binding protein -
MTX22_RS15940 (MTX22_15845) 3437095..3437496 - 402 WP_280984041.1 type II toxin-antitoxin system VapC family toxin Toxin
MTX22_RS15945 (MTX22_15850) 3437493..3437729 - 237 WP_280984042.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX22_RS15950 (MTX22_15855) 3438191..3438367 + 177 Protein_3161 integrase core domain-containing protein -
MTX22_RS15955 (MTX22_15860) 3438527..3440079 + 1553 Protein_3162 ISL3 family transposase -
MTX22_RS15960 (MTX22_15865) 3440562..3441023 + 462 WP_280984043.1 GNAT family N-acetyltransferase -
MTX22_RS15965 (MTX22_15870) 3441705..3441986 + 282 WP_280984044.1 tRNA 5-methylaminomethyl-2-thiouridine synthase -
MTX22_RS15970 (MTX22_15875) 3442235..3442615 - 381 WP_280984782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14219.39 Da        Isoelectric Point: 6.9532

>T239935 WP_280984041.1 NZ_CP094525:c3437496-3437095 [Bradyrhizobium sp. ISRA463]
VTRYLLDTNIISDLVRNPQGKVAKRIAKVGEANVCTSIIVASELRYGCAKAGSPRLTKAVEEILGEIPVLPFDVPADAEY
GVVRSELEAAGKPIGSNDLLIAAHASALSMTIVTANTDEFKRARGLKVTNWLD

Download         Length: 402 bp

>T239935 NZ_LS483409:c260157-259828 [Streptococcus gallolyticus]
TTGGATTATAAAATAAGTTATAACGCTGGTGCTTTGGAAGCATTGGTAGAAATAAAAGAATATATAATTAATAATTTCAA
GTCAGAAACATCAGCGAAAAAGGTAGTTGATAATATCATGCAAAAAATAAGTGCTTTAGAGATTTTTCCTGAAGTAGGGT
TTGATGCTGATGAAAGATTTGGAAAAACTTTAGATAAGCGTCATAAAACTAGAGGTTTAACAATCGGGAAAGATTATATA
GCTTTATATTTTGTTAATGATGAAAAAAAGGAAGTTGTCATTACCCATATTGTCTCAACTCGAAGTGATTATGTGAAATT
GTTCAAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9076.58 Da        Isoelectric Point: 10.4369

>AT239935 WP_280984042.1 NZ_CP094525:c3437729-3437493 [Bradyrhizobium sp. ISRA463]
MTQRRHVRLFRNGRNQAVRIPVEFEMPGDEATMFRDGDRLVIEPLRKRGLLALLKTMTPVAEHFPEIDDPAPKPERVL

Download         Length: 237 bp

>AT239935 NZ_LS483409:c260437-260147 [Streptococcus gallolyticus]
ATGGTAGTTGCAGAAAAAAATAGAGCCGTCACTTTTCAAGCTAATAAAGAATTAGTAAGCGAAGCTAAAGAAGTTTTAAA
TAAAAAGAATTTGACATTATCACATGCTTTAAGATTATTTTTACAAAATGTTGTTGTTACTAATGAAATTGACTTGTTGA
ACGAAGAAGAGCTAGAAAAAGAGAAGTTATTTAGACAACTTCAAGGAGAAATAAAGCAAGCTATAGATGATTATGAAGCT
GGTGTAAATACTTATTCAGCTGAAGAGGTGAGAAAACGTCTTGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References