Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 26947..27608 Replicon plasmid unnamed
Accession NZ_CP094524
Organism Bradyrhizobium sp. ISRA443

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX26_RS35075 Protein ID WP_280978507.1
Coordinates 26947..27354 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX26_RS35080 Protein ID WP_280978508.1
Coordinates 27354..27608 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX26_RS35040 (MTX26_34940) 23273..23890 + 618 WP_280978501.1 hypothetical protein -
MTX26_RS35045 (MTX26_34945) 23964..24203 + 240 WP_280978502.1 plasmid stabilization protein -
MTX26_RS35050 (MTX26_34950) 24304..24579 + 276 WP_280978503.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MTX26_RS35055 (MTX26_34955) 24566..25012 + 447 WP_280978504.1 plasmid maintenance toxin (PemK-like) -
MTX26_RS35060 (MTX26_34960) 25061..25483 - 423 WP_280978505.1 type II toxin-antitoxin system VapC family toxin -
MTX26_RS35065 (MTX26_34965) 25483..25749 - 267 WP_280978506.1 type II toxin-antitoxin system VapB family antitoxin -
MTX26_RS35070 (MTX26_34970) 25835..26881 - 1047 WP_280978620.1 site-specific integrase -
MTX26_RS35075 (MTX26_34975) 26947..27354 - 408 WP_280978507.1 type II toxin-antitoxin system VapC family toxin Toxin
MTX26_RS35080 (MTX26_34980) 27354..27608 - 255 WP_280978508.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX26_RS35085 (MTX26_34985) 27907..28848 + 942 WP_280978621.1 DUF1403 family protein -
MTX26_RS35090 (MTX26_34990) 28850..29542 + 693 WP_280978509.1 SMC-Scp complex subunit ScpB -
MTX26_RS35095 (MTX26_34995) 29508..30374 + 867 WP_280978510.1 hypothetical protein -
MTX26_RS35100 (MTX26_35000) 30756..32159 + 1404 WP_280978511.1 toll/interleukin-1 receptor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..316663 316663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14757.74 Da        Isoelectric Point: 6.3309

>T239934 WP_280978507.1 NZ_CP094524:c27354-26947 [Bradyrhizobium sp. ISRA443]
MYLVDTNVVSEARRGSAQATGWLRSVDPASVHLSTLTLGEIMRGIALKQKSDPKAAAHLAEWLRKLRHDHADRILAVTDQ
ISVEWGRIAAIRPRGDIDGQIAATAIVHDLILVTRNVGDFEDTGATVINPWEESA

Download         Length: 408 bp

>T239934 NZ_LS483408:1268096-1268941 [Streptococcus uberis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTACTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TATCAAATGTTATCGGAGTTGAATCTCGTAGCACTGTTGATATTGATTTTTTGTTCCATCAAATGACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAACCACAGCTAT
AAAAGAAAGTGATGACTATGGTGGCTATCGTGCAACCATTTTATGCCAACTTGAGAATATTAAACAAATTATCCATTTGG
ATATTGCAACTGGGGATATTGTAACTCCACAGCCTATTACATATGATTACAAAGCTATTTTTAATGAAGACACCTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGCAACTTCTTGAACAGCAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAATTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACTAAGGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9187.29 Da        Isoelectric Point: 4.7420

>AT239934 WP_280978508.1 NZ_CP094524:c27608-27354 [Bradyrhizobium sp. ISRA443]
MEWSLQDAKNQFSKVVQKARLEGPQVVTLRGERAAVVLSAADYDALRSGRPTLVDDLLAGPGWDDEMAEAVTRRANTPSR
DAAF

Download         Length: 255 bp

>AT239934 NZ_LS483408:1267509-1268099 [Streptococcus uberis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTATCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACGGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACACCTATGGGAAACAAGGTAA
GAGTGTATGATTTAGAACGCATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTATGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References