Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4296410..4297031 Replicon chromosome
Accession NZ_CP094523
Organism Bradyrhizobium sp. ISRA443

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX26_RS20415 Protein ID WP_280972003.1
Coordinates 4296630..4297031 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX26_RS20410 Protein ID WP_280972002.1
Coordinates 4296410..4296640 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX26_RS20385 (MTX26_20320) 4291910..4292152 - 243 WP_280971997.1 hypothetical protein -
MTX26_RS20390 (MTX26_20325) 4292173..4292952 - 780 WP_280971998.1 DUF899 domain-containing protein -
MTX26_RS20395 (MTX26_20330) 4293047..4294267 + 1221 WP_280971999.1 helix-turn-helix domain-containing protein -
MTX26_RS20400 (MTX26_20335) 4294301..4294945 + 645 WP_280972000.1 glutamine cyclotransferase -
MTX26_RS20405 (MTX26_20340) 4294998..4296212 - 1215 WP_280972001.1 MFS transporter -
MTX26_RS20410 (MTX26_20345) 4296410..4296640 + 231 WP_280972002.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX26_RS20415 (MTX26_20350) 4296630..4297031 + 402 WP_280972003.1 PIN domain-containing protein Toxin
MTX26_RS20420 (MTX26_20355) 4297039..4297131 + 93 Protein_4037 AAA family ATPase -
MTX26_RS20425 (MTX26_20360) 4297199..4298716 - 1518 WP_280972004.1 MFS transporter -
MTX26_RS20430 (MTX26_20365) 4298921..4299859 + 939 WP_280972005.1 LysR family transcriptional regulator -
MTX26_RS20435 (MTX26_20370) 4299886..4300563 - 678 WP_280972006.1 LysR substrate-binding domain-containing protein -
MTX26_RS20440 (MTX26_20375) 4300470..4300796 - 327 WP_280972007.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14887.11 Da        Isoelectric Point: 5.6254

>T239933 WP_280972003.1 NZ_CP094523:4296630-4297031 [Bradyrhizobium sp. ISRA443]
MPGDFFDTNVLVHLASGDPLKADRAEAVISRGGVISVQVLNEIANVARRKMRMSWTETRAFLTILRNLLTIYPLTQEIHD
AGLDLAERYGLSMFDAMIAASALQAGCDRLWSEDMQHNQVLDNSLRIVNPFRV

Download         Length: 402 bp

>T239933 NZ_LS483408:c1247250-1246480 [Streptococcus uberis]
ATGAGATTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTACAACGAACCATTCGGGCTTTAACCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCTGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCGATATCATTATCATTGATGGTGAAAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAATTGGTTGATGAACTTAGCAC
GCAAGGTTATCATTTGTTAATTGAAGGGACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACAGCTATTGAAATCAA
GGGGGTATAAAGTCTCATTAGCAATAATAGCAACCATGCCTGAATTGTCCTATCTCAGCACCTTAATCCGTTATGAGGAA
GTCTATGCAGTGAATCCAGGCCAAGCTAGAGCAACACCTAAAGAACATCACGATGGTATTGTAGAGCATTTGGTTGATAA
TCTAAGAGAGTTAGAAAACGATAAACTCTTTGATGAGATTCAAATTTACCAGAGAAACAGATGGTGTGTCTATGACTCTG
AAATTGATGATGGTCCGGCAGCAGAAGTGCTACAAGAACACCTCTTCGGAAAATGGAGTAAGGTCGAGGAAGAGATGTTG
AAGGTGGGACGGGAACGATTGAGAGAGTTTTCAGTAATGAAAGAAAATTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8600.81 Da        Isoelectric Point: 7.0171

>AT239933 WP_280972002.1 NZ_CP094523:4296410-4296640 [Bradyrhizobium sp. ISRA443]
MQVAKWGNSLAIRLPAAVVEALELKEGDEIEIHVADERNFGVARKPGREELLARLRAFRGRLPADFKFDRDEANAR

Download         Length: 231 bp

>AT239933 NZ_LS483408:c1247726-1247250 [Streptococcus uberis]
ATGATTGGGGACAACATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAGATGGTTGGGATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGAACCAGCACCGTATCAACAGAACTCATCGACCGCATTTGTCAGAAATTTA
ACGTCTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
AACAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References