Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2712652..2713271 Replicon chromosome
Accession NZ_CP094523
Organism Bradyrhizobium sp. ISRA443

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MTX26_RS12665 Protein ID WP_280976979.1
Coordinates 2713083..2713271 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MTX26_RS12660 Protein ID WP_280976978.1
Coordinates 2712652..2713044 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX26_RS12635 (MTX26_12620) 2708445..2709209 - 765 WP_280976973.1 flagellar basal-body rod protein FlgF -
MTX26_RS12640 (MTX26_12625) 2709591..2710079 + 489 WP_280976974.1 flagellar basal body-associated protein FliL -
MTX26_RS12645 (MTX26_12630) 2710098..2711300 + 1203 WP_280976975.1 flagellar motor switch protein FliM -
MTX26_RS12650 (MTX26_12635) 2711297..2711764 + 468 WP_280976976.1 DUF6468 domain-containing protein -
MTX26_RS12655 (MTX26_12640) 2711761..2712564 + 804 WP_280976977.1 flagellar protein FlbB -
MTX26_RS12660 (MTX26_12645) 2712652..2713044 - 393 WP_280976978.1 YlcI/YnfO family protein Antitoxin
MTX26_RS12665 (MTX26_12650) 2713083..2713271 - 189 WP_280976979.1 type II toxin-antitoxin system HicA family toxin Toxin
MTX26_RS12670 (MTX26_12655) 2713514..2717221 + 3708 WP_280976980.1 tetratricopeptide repeat protein -
MTX26_RS12675 (MTX26_12660) 2717435..2717770 + 336 WP_280976981.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2712652..2721324 8672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7024.27 Da        Isoelectric Point: 11.5372

>T239932 WP_280976979.1 NZ_CP094523:c2713271-2713083 [Bradyrhizobium sp. ISRA443]
MRSTDLIKAMLADGWRQVSQKGSHVQFKHLTKPSRVTVPHPKRDIPVGTFKSIEKQSGLKLK

Download         Length: 189 bp

>T239932 NZ_LS483407:1576710-1577045 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13854.55 Da        Isoelectric Point: 4.2850

>AT239932 WP_280976978.1 NZ_CP094523:c2713044-2712652 [Bradyrhizobium sp. ISRA443]
MRHYIALIHKDADSDYGVSFPDLPGVITSGTDLDDARTMAAEALALHLEGLAEDGEAVPEPSSLEKIMADVENRDGVAVL
IPAPSEGVKSVRVNITLPSDILNEIDRRAEQEGFTRSGFLAQAARKALAA

Download         Length: 393 bp

>AT239932 NZ_LS483407:1576433-1576720 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References