Detailed information of TA system TA239929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2712652..2713271
• Replicon: chromosome
• Accession: NZ_CP094521
• Organism: Bradyrhizobium sp. ISRA437

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MTX18_RS12665
• Protein ID: WP_280976979.1
• Coordinates: 2713083..2713271 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MTX18_RS12660
• Protein ID: WP_280976978.1
• Coordinates: 2712652..2713044 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX18_RS12635 (MTX18_12620)	2708445..2709209	-	765	WP_280976973.1	flagellar basal-body rod protein FlgF	-
MTX18_RS12640 (MTX18_12625)	2709591..2710079	+	489	WP_280976974.1	flagellar basal body-associated protein FliL	-
MTX18_RS12645 (MTX18_12630)	2710098..2711300	+	1203	WP_280976975.1	flagellar motor switch protein FliM	-
MTX18_RS12650 (MTX18_12635)	2711297..2711764	+	468	WP_280976976.1	DUF6468 domain-containing protein	-
MTX18_RS12655 (MTX18_12640)	2711761..2712564	+	804	WP_280976977.1	flagellar protein FlbB	-
MTX18_RS12660 (MTX18_12645)	2712652..2713044	-	393	WP_280976978.1	YlcI/YnfO family protein	Antitoxin
MTX18_RS12665 (MTX18_12650)	2713083..2713271	-	189	WP_280976979.1	type II toxin-antitoxin system HicA family toxin	Toxin
MTX18_RS12670 (MTX18_12655)	2713514..2717221	+	3708	WP_280976980.1	tetratricopeptide repeat protein	-
MTX18_RS12675 (MTX18_12660)	2717435..2717770	+	336	WP_280976981.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2712652..2721324	8672

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7024.27 Da
• Isoelectric Point: 11.5372

>T239929 WP_280976979.1 NZ_CP094521:c2713271-2713083 [Bradyrhizobium sp. ISRA437]
MRSTDLIKAMLADGWRQVSQKGSHVQFKHLTKPSRVTVPHPKRDIPVGTFKSIEKQSGLKLK

Nucleotide

• Length: 189 bp

>T239929 NZ_LS483406:263243-263548 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13854.55 Da
• Isoelectric Point: 4.2850

>AT239929 WP_280976978.1 NZ_CP094521:c2713044-2712652 [Bradyrhizobium sp. ISRA437]
MRHYIALIHKDADSDYGVSFPDLPGVITSGTDLDDARTMAAEALALHLEGLAEDGEAVPEPSSLEKIMADVENRDGVAVL
IPAPSEGVKSVRVNITLPSDILNEIDRRAEQEGFTRSGFLAQAARKALAA

Nucleotide

• Length: 393 bp

>AT239929 NZ_LS483406:263589-263891 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA