Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 179243..179904 Replicon plasmid unnamed
Accession NZ_CP094520
Organism Bradyrhizobium sp. ISRA436

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX23_RS35740 Protein ID WP_280978507.1
Coordinates 179497..179904 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX23_RS35735 Protein ID WP_280978508.1
Coordinates 179243..179497 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX23_RS35715 (MTX23_35625) 174692..176095 - 1404 WP_280978511.1 toll/interleukin-1 receptor domain-containing protein -
MTX23_RS35720 (MTX23_35630) 176477..177343 - 867 WP_280978510.1 hypothetical protein -
MTX23_RS35725 (MTX23_35635) 177309..178001 - 693 WP_280978509.1 SMC-Scp complex subunit ScpB -
MTX23_RS35730 (MTX23_35640) 178003..178944 - 942 WP_280978621.1 DUF1403 family protein -
MTX23_RS35735 (MTX23_35645) 179243..179497 + 255 WP_280978508.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTX23_RS35740 (MTX23_35650) 179497..179904 + 408 WP_280978507.1 type II toxin-antitoxin system VapC family toxin Toxin
MTX23_RS35745 (MTX23_35655) 179970..181016 + 1047 WP_280978620.1 site-specific integrase -
MTX23_RS35750 (MTX23_35660) 181102..181368 + 267 WP_280978506.1 type II toxin-antitoxin system VapB family antitoxin -
MTX23_RS35755 (MTX23_35665) 181368..181790 + 423 WP_280978505.1 type II toxin-antitoxin system VapC family toxin -
MTX23_RS35760 (MTX23_35670) 181839..182285 - 447 WP_280978504.1 plasmid maintenance toxin (PemK-like) -
MTX23_RS35765 (MTX23_35675) 182272..182547 - 276 WP_280978503.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MTX23_RS35770 (MTX23_35680) 182648..182887 - 240 WP_280978502.1 plasmid stabilization protein -
MTX23_RS35775 (MTX23_35685) 182961..183578 - 618 WP_280978501.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..316663 316663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14757.74 Da        Isoelectric Point: 6.3309

>T239928 WP_280978507.1 NZ_CP094520:179497-179904 [Bradyrhizobium sp. ISRA436]
MYLVDTNVVSEARRGSAQATGWLRSVDPASVHLSTLTLGEIMRGIALKQKSDPKAAAHLAEWLRKLRHDHADRILAVTDQ
ISVEWGRIAAIRPRGDIDGQIAATAIVHDLILVTRNVGDFEDTGATVINPWEESA

Download         Length: 408 bp

>T239928 NZ_LS483406:c104963-103641 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCAGGTCTGGATGAATGGTGTGGAAGTCGCACTTTGGGATGATGTCCGGAACGGGTCATCCCGGTTGTC
GTATGTCAGCCAGTGGATCAGCTCGCCCCAGTCCCGACCGTTGTCGCTCTCTCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCGCCATACGCAACCGGATCCGCGACCGG
TTCGCCACGCGCGGCAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGGGATTGTGTCGGCGCAGTGCAGCTGTTGCC
GCCTGCGCATCCACCCGAAGACATCCAGCAGATCACGTGCGAGGTGTTGGACGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGATGCATTCCGCATTTCCATCGCCGGTGCGCAGGAAAAG
ACCGGTCTTCTGCTGCATGCTGGCAAATGGTGCATTCCTACCGGCAACACACCATCCACTCACATCTTCAAGCTGCCGCT
TGGCATTGTTGGCAACATGCGGGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCCT
TTGATATCCCCGTGGCCGAGACGCAGATGGGCCGCTTCAACGACCAACGTGCTCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGCCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGTCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCCGGTATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGCCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCAGGGGACCCAATCAACT
CGATCCACGAAACGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCGACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAG
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGACTTCCCCTCAAACGTGTCCGAACCGATTTTCAACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9187.29 Da        Isoelectric Point: 4.7420

>AT239928 WP_280978508.1 NZ_CP094520:179243-179497 [Bradyrhizobium sp. ISRA436]
MEWSLQDAKNQFSKVVQKARLEGPQVVTLRGERAAVVLSAADYDALRSGRPTLVDDLLAGPGWDDEMAEAVTRRANTPSR
DAAF

Download         Length: 255 bp

>AT239928 NZ_LS483406:c105224-104967 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACAGTGAGGACAGCCCAACAACTTGCGCCCCTGATGCGTGCTTTCCGGCGCCAGGCGGGCCT
GAGCCAGGCTCAGCTGGCGGAGCGACTCGGGATCAGCCGCCAGGCAGTGGGCGCGCTGGAACGCGACCCTGCATCGGCAA
GTTTTGAACGCCTGATGCGGATCTGGGCGGTGCTGGGTCTGGAGGTCAGCCTCCAGCAACGAAGTCCCCAGGAGAACACG
TCGTCATTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References