Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4297842..4298463 Replicon chromosome
Accession NZ_CP094519
Organism Bradyrhizobium sp. ISRA436

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX23_RS20415 Protein ID WP_280972003.1
Coordinates 4298062..4298463 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX23_RS20410 Protein ID WP_280972002.1
Coordinates 4297842..4298072 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX23_RS20385 (MTX23_20320) 4293342..4293584 - 243 WP_280971997.1 hypothetical protein -
MTX23_RS20390 (MTX23_20325) 4293605..4294384 - 780 WP_280971998.1 DUF899 domain-containing protein -
MTX23_RS20395 (MTX23_20330) 4294479..4295699 + 1221 WP_280971999.1 helix-turn-helix domain-containing protein -
MTX23_RS20400 (MTX23_20335) 4295733..4296377 + 645 WP_280972000.1 glutamine cyclotransferase -
MTX23_RS20405 (MTX23_20340) 4296430..4297644 - 1215 WP_280972001.1 MFS transporter -
MTX23_RS20410 (MTX23_20345) 4297842..4298072 + 231 WP_280972002.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTX23_RS20415 (MTX23_20350) 4298062..4298463 + 402 WP_280972003.1 PIN domain-containing protein Toxin
MTX23_RS20420 (MTX23_20355) 4298471..4298563 + 93 Protein_4037 AAA family ATPase -
MTX23_RS20425 (MTX23_20360) 4298631..4300148 - 1518 WP_280972004.1 MFS transporter -
MTX23_RS20430 (MTX23_20365) 4300353..4301291 + 939 WP_280972005.1 LysR family transcriptional regulator -
MTX23_RS20435 (MTX23_20370) 4301318..4301995 - 678 WP_280972006.1 LysR substrate-binding domain-containing protein -
MTX23_RS20440 (MTX23_20375) 4301902..4302228 - 327 WP_280972007.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14887.11 Da        Isoelectric Point: 5.6254

>T239927 WP_280972003.1 NZ_CP094519:4298062-4298463 [Bradyrhizobium sp. ISRA436]
MPGDFFDTNVLVHLASGDPLKADRAEAVISRGGVISVQVLNEIANVARRKMRMSWTETRAFLTILRNLLTIYPLTQEIHD
AGLDLAERYGLSMFDAMIAASALQAGCDRLWSEDMQHNQVLDNSLRIVNPFRV

Download         Length: 402 bp

>T239927 NZ_LS483401:1555457-1555792 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8600.81 Da        Isoelectric Point: 7.0171

>AT239927 WP_280972002.1 NZ_CP094519:4297842-4298072 [Bradyrhizobium sp. ISRA436]
MQVAKWGNSLAIRLPAAVVEALELKEGDEIEIHVADERNFGVARKPGREELLARLRAFRGRLPADFKFDRDEANAR

Download         Length: 231 bp

>AT239927 NZ_LS483401:1555180-1555467 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References