Detailed information of TA system TA239926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2714084..2714703
• Replicon: chromosome
• Accession: NZ_CP094519
• Organism: Bradyrhizobium sp. ISRA436

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MTX23_RS12675
• Protein ID: WP_280976979.1
• Coordinates: 2714515..2714703 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MTX23_RS12670
• Protein ID: WP_280976978.1
• Coordinates: 2714084..2714476 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX23_RS12645 (MTX23_12630)	2709877..2710641	-	765	WP_280976973.1	flagellar basal-body rod protein FlgF	-
MTX23_RS12650 (MTX23_12635)	2711023..2711511	+	489	WP_280976974.1	flagellar basal body-associated protein FliL	-
MTX23_RS12655 (MTX23_12640)	2711530..2712732	+	1203	WP_280976975.1	flagellar motor switch protein FliM	-
MTX23_RS12660 (MTX23_12645)	2712729..2713196	+	468	WP_280976976.1	DUF6468 domain-containing protein	-
MTX23_RS12665 (MTX23_12650)	2713193..2713996	+	804	WP_280976977.1	flagellar protein FlbB	-
MTX23_RS12670 (MTX23_12655)	2714084..2714476	-	393	WP_280976978.1	YlcI/YnfO family protein	Antitoxin
MTX23_RS12675 (MTX23_12660)	2714515..2714703	-	189	WP_280976979.1	type II toxin-antitoxin system HicA family toxin	Toxin
MTX23_RS12680 (MTX23_12665)	2714946..2718653	+	3708	WP_280976980.1	tetratricopeptide repeat protein	-
MTX23_RS12685 (MTX23_12670)	2718867..2719202	+	336	WP_280976981.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2714084..2722756	8672

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7024.27 Da
• Isoelectric Point: 11.5372

>T239926 WP_280976979.1 NZ_CP094519:c2714703-2714515 [Bradyrhizobium sp. ISRA436]
MRSTDLIKAMLADGWRQVSQKGSHVQFKHLTKPSRVTVPHPKRDIPVGTFKSIEKQSGLKLK

Nucleotide

• Length: 189 bp

>T239926 NZ_LS483399:1584304-1584639 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13854.55 Da
• Isoelectric Point: 4.2850

>AT239926 WP_280976978.1 NZ_CP094519:c2714476-2714084 [Bradyrhizobium sp. ISRA436]
MRHYIALIHKDADSDYGVSFPDLPGVITSGTDLDDARTMAAEALALHLEGLAEDGEAVPEPSSLEKIMADVENRDGVAVL
IPAPSEGVKSVRVNITLPSDILNEIDRRAEQEGFTRSGFLAQAARKALAA

Nucleotide

• Length: 393 bp

>AT239926 NZ_LS483399:1584027-1584314 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA