Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2294635..2295308 Replicon chromosome
Accession NZ_CP094517
Organism Bradyrhizobium sp. ISRA432

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTX25_RS10535 Protein ID WP_280969128.1
Coordinates 2294886..2295308 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTX25_RS10530 Protein ID WP_280969127.1
Coordinates 2294635..2294889 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX25_RS10515 (MTX25_10470) 2291332..2292021 + 690 WP_280970898.1 YopT-type cysteine protease domain-containing protein -
MTX25_RS10520 (MTX25_10475) 2293517..2293843 + 327 WP_280969126.1 IS66 family insertion sequence element accessory protein TnpB -
MTX25_RS10525 (MTX25_10480) 2293934..2294563 + 630 Protein_2081 IS66 family transposase zinc-finger binding domain-containing protein -
MTX25_RS10530 (MTX25_10485) 2294635..2294889 + 255 WP_280969127.1 plasmid stabilization protein Antitoxin
MTX25_RS10535 (MTX25_10490) 2294886..2295308 + 423 WP_280969128.1 type II toxin-antitoxin system VapC family toxin Toxin
MTX25_RS10540 (MTX25_10495) 2295584..2295904 - 321 Protein_2084 transposase -
MTX25_RS10545 (MTX25_10500) 2296795..2298339 - 1545 WP_280969129.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2275146..2298411 23265
- flank IS/Tn - - 2293517..2293843 326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14900.11 Da        Isoelectric Point: 5.7030

>T239925 WP_280969128.1 NZ_CP094517:2294886-2295308 [Bradyrhizobium sp. ISRA432]
MILLDTNVVSEAMKPDPHPTVRDWLDAQAAETLFLSSVTIAELLFGIGALPRGKRKDRLAAALDGVLDLFATRILPFDTD
AARRYAELAVKARTAGKGFPTPDGYIAAIAAAHGFAVASRDTSAFNAVGLTMIDPWTVTS

Download         Length: 423 bp

>T239925 NZ_LS483398:c3106273-3104933 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9265.54 Da        Isoelectric Point: 7.2070

>AT239925 WP_280969127.1 NZ_CP094517:2294635-2294889 [Bradyrhizobium sp. ISRA432]
MAAVTIRNLSEEAHRALKVRAAQHNRSAEAEMRAILEAAVRPEGRLQLGTALSEMSRKIGLTNADVEALEQGRDARPAEP
MRFE

Download         Length: 255 bp

>AT239925 NZ_LS483398:c3106532-3106275 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References