Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 2294872..2295545 | Replicon | chromosome |
Accession | NZ_CP094515 | ||
Organism | Bradyrhizobium sp. ISRA426 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | MTX24_RS10525 | Protein ID | WP_280969128.1 |
Coordinates | 2295123..2295545 (+) | Length | 141 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | MTX24_RS10520 | Protein ID | WP_280969127.1 |
Coordinates | 2294872..2295126 (+) | Length | 85 a.a. |
Genomic Context
Location: 2291569..2292258 (690 bp)
Type: Others
Protein ID: WP_280970898.1
Type: Others
Protein ID: WP_280970898.1
Location: 2293754..2294080 (327 bp)
Type: Others
Protein ID: WP_280969126.1
Type: Others
Protein ID: WP_280969126.1
Location: 2294171..2294800 (630 bp)
Type: Others
Protein ID: Protein_2079
Type: Others
Protein ID: Protein_2079
Location: 2294872..2295126 (255 bp)
Type: Antitoxin
Protein ID: WP_280969127.1
Type: Antitoxin
Protein ID: WP_280969127.1
Location: 2295123..2295545 (423 bp)
Type: Toxin
Protein ID: WP_280969128.1
Type: Toxin
Protein ID: WP_280969128.1
Location: 2295821..2296141 (321 bp)
Type: Others
Protein ID: Protein_2082
Type: Others
Protein ID: Protein_2082
Location: 2297032..2298576 (1545 bp)
Type: Others
Protein ID: WP_280969129.1
Type: Others
Protein ID: WP_280969129.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTX24_RS10505 (MTX24_10460) | 2291569..2292258 | + | 690 | WP_280970898.1 | YopT-type cysteine protease domain-containing protein | - |
MTX24_RS10510 (MTX24_10465) | 2293754..2294080 | + | 327 | WP_280969126.1 | IS66 family insertion sequence element accessory protein TnpB | - |
MTX24_RS10515 (MTX24_10470) | 2294171..2294800 | + | 630 | Protein_2079 | IS66 family transposase zinc-finger binding domain-containing protein | - |
MTX24_RS10520 (MTX24_10475) | 2294872..2295126 | + | 255 | WP_280969127.1 | plasmid stabilization protein | Antitoxin |
MTX24_RS10525 (MTX24_10480) | 2295123..2295545 | + | 423 | WP_280969128.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MTX24_RS10530 (MTX24_10485) | 2295821..2296141 | - | 321 | Protein_2082 | transposase | - |
MTX24_RS10535 (MTX24_10490) | 2297032..2298576 | - | 1545 | WP_280969129.1 | acyl-CoA dehydrogenase family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2275383..2298648 | 23265 | |
- | flank | IS/Tn | - | - | 2293754..2294080 | 326 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 14900.11 Da Isoelectric Point: 5.7030
>T239923 WP_280969128.1 NZ_CP094515:2295123-2295545 [Bradyrhizobium sp. ISRA426]
MILLDTNVVSEAMKPDPHPTVRDWLDAQAAETLFLSSVTIAELLFGIGALPRGKRKDRLAAALDGVLDLFATRILPFDTD
AARRYAELAVKARTAGKGFPTPDGYIAAIAAAHGFAVASRDTSAFNAVGLTMIDPWTVTS
MILLDTNVVSEAMKPDPHPTVRDWLDAQAAETLFLSSVTIAELLFGIGALPRGKRKDRLAAALDGVLDLFATRILPFDTD
AARRYAELAVKARTAGKGFPTPDGYIAAIAAAHGFAVASRDTSAFNAVGLTMIDPWTVTS
Download Length: 423 bp
>T239923 NZ_LS483396:c309291-309037 [Micrococcus luteus NCTC 2665]
ATGCGCCTCGTGTCGGACCGCTCCGCCTGGGATGACTGCACGCACTGGCAGACCACGGACCGCAAGGTCCTCCAACGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCCTCGACGGGATCGGCAAACCCGAGCAGCTGAAGTACGGCGCGGCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA
ATGCGCCTCGTGTCGGACCGCTCCGCCTGGGATGACTGCACGCACTGGCAGACCACGGACCGCAAGGTCCTCCAACGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCCTCGACGGGATCGGCAAACCCGAGCAGCTGAAGTACGGCGCGGCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9265.54 Da Isoelectric Point: 7.2070
>AT239923 WP_280969127.1 NZ_CP094515:2294872-2295126 [Bradyrhizobium sp. ISRA426]
MAAVTIRNLSEEAHRALKVRAAQHNRSAEAEMRAILEAAVRPEGRLQLGTALSEMSRKIGLTNADVEALEQGRDARPAEP
MRFE
MAAVTIRNLSEEAHRALKVRAAQHNRSAEAEMRAILEAAVRPEGRLQLGTALSEMSRKIGLTNADVEALEQGRDARPAEP
MRFE
Download Length: 255 bp
>AT239923 NZ_LS483396:c309495-309292 [Micrococcus luteus NCTC 2665]
GTGCCTCCCGAGTTCGACCTCGCCGACTGGTACATAAGCAGGCACCACATCGCGCCGGAGGAGGCCCCCATGTCCATCAG
TGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGACTGCGGACCGCGACGCCGTCGAGATCGTCTCCC
GCAAGGGCAACGCCGTTCTCATGCCCGCGGACGGGGACGCCTGA
GTGCCTCCCGAGTTCGACCTCGCCGACTGGTACATAAGCAGGCACCACATCGCGCCGGAGGAGGCCCCCATGTCCATCAG
TGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGACTGCGGACCGCGACGCCGTCGAGATCGTCTCCC
GCAAGGGCAACGCCGTTCTCATGCCCGCGGACGGGGACGCCTGA