Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3912124..3912743 Replicon chromosome
Accession NZ_CP094512
Organism Klebsiella pneumoniae strain SHX180

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MTX44_RS19085 Protein ID WP_002892050.1
Coordinates 3912525..3912743 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MTX44_RS19080 Protein ID WP_002892066.1
Coordinates 3912124..3912498 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX44_RS19070 (MTX44_19030) 3907276..3908469 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MTX44_RS19075 (MTX44_19035) 3908492..3911638 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MTX44_RS19080 (MTX44_19040) 3912124..3912498 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MTX44_RS19085 (MTX44_19045) 3912525..3912743 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MTX44_RS19090 (MTX44_19050) 3912902..3913468 + 567 WP_094313731.1 maltose O-acetyltransferase -
MTX44_RS19095 (MTX44_19055) 3913440..3913580 - 141 WP_004147370.1 hypothetical protein -
MTX44_RS19100 (MTX44_19060) 3913601..3914071 + 471 WP_002892026.1 YlaC family protein -
MTX44_RS19105 (MTX44_19065) 3914046..3915497 - 1452 WP_213222697.1 PLP-dependent aminotransferase family protein -
MTX44_RS19110 (MTX44_19070) 3915598..3916296 + 699 WP_004177238.1 GNAT family protein -
MTX44_RS19115 (MTX44_19075) 3916293..3916433 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MTX44_RS19120 (MTX44_19080) 3916433..3916696 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T239918 WP_002892050.1 NZ_CP094512:3912525-3912743 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T239918 NZ_LS483395:156589-156867 [Achromobacter xylosoxidans]
ATGCTCGACGTATCCTGGCTTCAAACCGCCGCAGACGATCTGGCGGGGATCATCTCCTACATCGCCGAGCGTAGTCCGCA
GGCGGCACGCGACCTCCGGCAACGCATCGACAATGCCGTGCTGTCCCTGGCGCGGCACCCTTGCCGATATCGAGCCGGCC
GCGTCTCTGGCACGCGCGAATGCGTCGTACACCCTAATTACGTGGTGGTCTACCGGGTGACCGCGTTGGCGATCGAGGTC
GTCAACATCGTGCACGCCCGCCGGGAATATCCCCCCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT239918 WP_002892066.1 NZ_CP094512:3912124-3912498 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT239918 NZ_LS483395:156313-156519 [Achromobacter xylosoxidans]
ATGGGCCCAATCCCTTCCTCCATCCTCTCGGAATTCGAGACCGAAGAACAGGCGGTCAGCTACGACCGCTGGTTCCGCGC
GAAGGTGCAAGCCAGCCTGGACGATCCGCGTCCCGCCGTTTCGCATCAAAGGGTGATGGCCCGCATCGATGCCATTATCG
AAACGGCGTGCCGTCGTCAGCTGGATCCGCAAGACGGAGAAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References