Detailed information of TA system TA239917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2551979..2553567
• Replicon: chromosome
• Accession: NZ_CP094512
• Organism: Klebsiella pneumoniae strain SHX180

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MTX44_RS12580
• Protein ID: WP_064151580.1
• Coordinates: 2551979..2553301 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MTX44_RS12585
• Protein ID: WP_004176198.1
• Coordinates: 2553301..2553567 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX44_RS12565 (MTX44_12530)	2547036..2549537	+	2502	WP_004184030.1	fimbria/pilus outer membrane usher protein	-
MTX44_RS12570 (MTX44_12535)	2549525..2550528	+	1004	Protein_2459	type 1 fimbrial protein	-
MTX44_RS12575 (MTX44_12540)	2550670..2551962	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MTX44_RS12580 (MTX44_12545)	2551979..2553301	-	1323	WP_064151580.1	type II toxin-antitoxin system HipA family toxin	Toxin
MTX44_RS12585 (MTX44_12550)	2553301..2553567	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MTX44_RS12590 (MTX44_12555)	2553954..2554280	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
MTX44_RS12595 (MTX44_12560)	2554277..2554777	-	501	WP_064158856.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MTX44_RS12600 (MTX44_12565)	2554755..2556134	-	1380	WP_064158857.1	nucleobase:cation symporter-2 family protein	-
MTX44_RS12605 (MTX44_12570)	2556480..2557634	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MTX44_RS12610 (MTX44_12575)	2557615..2558538	-	924	WP_064158859.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T239917 WP_064151580.1 NZ_CP094512:c2553301-2551979 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T239917 NZ_LS483394:1531491-1531826 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TGGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT239917 WP_004176198.1 NZ_CP094512:c2553567-2553301 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT239917 NZ_LS483394:1531214-1531501 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA