Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 830881..831538 Replicon chromosome
Accession NZ_CP094512
Organism Klebsiella pneumoniae strain SHX180

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MTX44_RS04155 Protein ID WP_002916310.1
Coordinates 831128..831538 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MTX44_RS04150 Protein ID WP_002916312.1
Coordinates 830881..831147 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX44_RS04125 (MTX44_04125) 826037..827470 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
MTX44_RS04130 (MTX44_04130) 827589..828317 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MTX44_RS04135 (MTX44_04135) 828367..828678 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MTX44_RS04140 (MTX44_04140) 828842..829501 + 660 WP_002916317.1 hemolysin III family protein -
MTX44_RS04145 (MTX44_04145) 829652..830635 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MTX44_RS04150 (MTX44_04150) 830881..831147 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MTX44_RS04155 (MTX44_04155) 831128..831538 + 411 WP_002916310.1 protein YgfX Toxin
MTX44_RS04160 (MTX44_04160) 831545..832066 - 522 WP_004144730.1 flavodoxin FldB -
MTX44_RS04165 (MTX44_04165) 832167..833063 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MTX44_RS04170 (MTX44_04170) 833086..833799 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MTX44_RS04175 (MTX44_04175) 833805..835538 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T239908 WP_002916310.1 NZ_CP094512:831128-831538 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T239908 NZ_LS483392:212270-212671 [Haemophilus influenzae]
ATGTATATGCTTGATACCAATACAGTAAGTGATATTGTCCGCAAAGATCCCAATGTTATTAGGCAGCTTAAGTCTCTTTC
TCCGGAAAGTATTTGTATTTCGGGAATTACGGCGGCGGAGATCATTTATGGATTGGAAAAGCGACAAAGTACCAAATTAA
ACCAAGTGATGTACCCATTTTTAGAGGTCGTAACCATTTATGATTGGCATTATGGTGTCGCACAATGTTATGGTAAATTG
CGTGCTAAGATGGAAAAGCAAGGTTTTGTAATGGGAGCCTTAGACCTTATGATCGCTGCACACGCTGTTTCAGAGAATTG
CACGTTAGTGACTAGCGACAACGCCTTTAAAATGGTTCCTGATCTAATTATTCAAAATTGGCGAGAAGAGCACAATATAT
AA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT239908 WP_002916312.1 NZ_CP094512:830881-831147 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239908 NZ_LS483392:212007-212270 [Haemophilus influenzae]
ATGGAACGAGTTGCAAGCCTGTTCAAAAATGGCCGAAGTCAAGCGGTCAGATTACCTGTTGATTTTGAGTTTAATGCGAA
GCAAATTTATATCCGCAAAGAAGCCAATGGTGATGTTGTTTTATCAATGCGCTCACAACAACAATCTTCTTGGGATAAAA
TGTGGTCAGCCTTAGATAACCTTGATACCGTTGATTTTTTAACACCTGAAGAGCGTCGCCAGGAACTATCTGCTCAAGAT
CCCTTTGAGGGAATCAACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References