Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 18960..19485 | Replicon | plasmid ps01 |
| Accession | NZ_CP094480 | ||
| Organism | Klebsiella pneumoniae strain LXR-1 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | - |
| Locus tag | MST28_RS25925 | Protein ID | WP_243440364.1 |
| Coordinates | 19180..19485 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | - |
| Locus tag | MST28_RS25920 | Protein ID | WP_243440363.1 |
| Coordinates | 18960..19178 (+) | Length | 73 a.a. |
Genomic Context
Location: 14875..15843 (969 bp)
Type: Others
Protein ID: WP_000654811.1
Type: Others
Protein ID: WP_000654811.1
Location: 18960..19178 (219 bp)
Type: Antitoxin
Protein ID: WP_243440363.1
Type: Antitoxin
Protein ID: WP_243440363.1
Location: 19180..19485 (306 bp)
Type: Toxin
Protein ID: WP_243440364.1
Type: Toxin
Protein ID: WP_243440364.1
Location: 19665..20407 (743 bp)
Type: Others
Protein ID: Protein_22
Type: Others
Protein ID: Protein_22
Location: 20563..21252 (690 bp)
Type: Others
Protein ID: Protein_23
Type: Others
Protein ID: Protein_23
Location: 22743..23171 (429 bp)
Type: Others
Protein ID: WP_152135175.1
Type: Others
Protein ID: WP_152135175.1
Location: 14332..14568 (237 bp)
Type: Others
Protein ID: Protein_14
Type: Others
Protein ID: Protein_14
Location: 15888..16364 (477 bp)
Type: Others
Protein ID: WP_243440362.1
Type: Others
Protein ID: WP_243440362.1
Location: 16584..17564 (981 bp)
Type: Others
Protein ID: WP_117146412.1
Type: Others
Protein ID: WP_117146412.1
Location: 17720..18136 (417 bp)
Type: Others
Protein ID: WP_229302433.1
Type: Others
Protein ID: WP_229302433.1
Location: 18133..18363 (231 bp)
Type: Others
Protein ID: WP_001261276.1
Type: Others
Protein ID: WP_001261276.1
Location: 21720..22607 (888 bp)
Type: Others
Protein ID: WP_243440365.1
Type: Others
Protein ID: WP_243440365.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MST28_RS25890 (MST28_25890) | 14332..14568 | - | 237 | Protein_14 | transposase | - |
| MST28_RS25895 (MST28_25895) | 14875..15843 | + | 969 | WP_000654811.1 | IS5 family transposase | - |
| MST28_RS25900 (MST28_25900) | 15888..16364 | - | 477 | WP_243440362.1 | hypothetical protein | - |
| MST28_RS25905 (MST28_25905) | 16584..17564 | - | 981 | WP_117146412.1 | hypothetical protein | - |
| MST28_RS25910 (MST28_25910) | 17720..18136 | - | 417 | WP_229302433.1 | type II toxin-antitoxin system VapC family toxin | - |
| MST28_RS25915 (MST28_25915) | 18133..18363 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| MST28_RS25920 (MST28_25920) | 18960..19178 | + | 219 | WP_243440363.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| MST28_RS25925 (MST28_25925) | 19180..19485 | + | 306 | WP_243440364.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| MST28_RS25930 (MST28_25930) | 19665..20407 | + | 743 | Protein_22 | hypothetical protein | - |
| MST28_RS25935 (MST28_25935) | 20563..21252 | + | 690 | Protein_23 | helix-turn-helix transcriptional regulator | - |
| MST28_RS25940 (MST28_25940) | 21720..22607 | - | 888 | WP_243440365.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| MST28_RS25945 (MST28_25945) | 22743..23171 | + | 429 | WP_152135175.1 | Rrf2 family transcriptional regulator | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | fimB / pla / allS / allA / allR / allB / allC / allD / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE / pla | 1..228721 | 228721 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.29 Da Isoelectric Point: 6.4661
>T239904 WP_243440364.1 NZ_CP094480:19180-19485 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTLGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGV
MQFKVYAYKRESRYRLFVDVQSDIIDTLGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGV
Download Length: 306 bp
>T239904 NZ_LS483390:c1568072-1567818 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8329.24 Da Isoelectric Point: 4.7205
>AT239904 WP_243440363.1 NZ_CP094480:18960-19178 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISGLVNRAMQNEARRLRAEHWQAENQEGMAEVARFIDMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNRAMQNEARRLRAEHWQAENQEGMAEVARFIDMNGSFADENRDW
Download Length: 219 bp
>AT239904 NZ_LS483390:c1568330-1568076 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA