Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4646081..4646784 | Replicon | chromosome |
| Accession | NZ_CP094479 | ||
| Organism | Klebsiella pneumoniae strain LXR-1 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A8T6BCS1 |
| Locus tag | MST28_RS22870 | Protein ID | WP_001616568.1 |
| Coordinates | 4646081..4646422 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A377WBK0 |
| Locus tag | MST28_RS22875 | Protein ID | WP_053274373.1 |
| Coordinates | 4646443..4646784 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MST28_RS22840 (4641103) | 4641103..4641369 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| MST28_RS22845 (4641369) | 4641369..4642041 | + | 673 | Protein_4480 | DUF4400 domain-containing protein | - |
| MST28_RS22850 (4642052) | 4642052..4642936 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| MST28_RS22855 (4643135) | 4643135..4643323 | - | 189 | Protein_4482 | transposase | - |
| MST28_RS22860 (4643340) | 4643340..4644451 | - | 1112 | Protein_4483 | IS3 family transposase | - |
| MST28_RS22865 (4644819) | 4644819..4645826 | - | 1008 | WP_049017154.1 | restriction endonuclease | - |
| MST28_RS22870 (4646081) | 4646081..4646422 | - | 342 | WP_001616568.1 | TA system toxin CbtA family protein | Toxin |
| MST28_RS22875 (4646443) | 4646443..4646784 | - | 342 | WP_053274373.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MST28_RS22880 (4646795) | 4646795..4647337 | - | 543 | WP_062896416.1 | DNA repair protein RadC | - |
| MST28_RS22885 (4647350) | 4647350..4647790 | - | 441 | WP_053274374.1 | antirestriction protein | - |
| MST28_RS22890 (4647821) | 4647821..4648642 | - | 822 | WP_243440249.1 | DUF932 domain-containing protein | - |
| MST28_RS22895 (4648740) | 4648740..4648970 | - | 231 | WP_053274376.1 | DUF905 domain-containing protein | - |
| MST28_RS22900 (4649042) | 4649042..4649491 | - | 450 | WP_243440250.1 | IrmA family protein | - |
| MST28_RS22905 (4649488) | 4649488..4649943 | - | 456 | WP_000754598.1 | hypothetical protein | - |
| MST28_RS22910 (4649982) | 4649982..4650617 | - | 636 | WP_053274379.1 | hypothetical protein | - |
| MST28_RS22915 (4650614) | 4650614..4651327 | - | 714 | WP_243440251.1 | sporulation transcriptional regulator SpoIIID | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4635214..4667224 | 32010 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12746.75 Da Isoelectric Point: 9.6548
>T239898 WP_001616568.1 NZ_CP094479:c4646422-4646081 [Klebsiella pneumoniae]
MKTLPATTPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T239898 NZ_LS483386:1678022-1678357 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12773.41 Da Isoelectric Point: 6.6253
>AT239898 WP_053274373.1 NZ_CP094479:c4646784-4646443 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 342 bp
>AT239898 NZ_LS483386:1677745-1678032 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAATAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
ATGACTACAGTAAAAAAAAATAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|