Detailed information of TA system TA239894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2637112..2638700
• Replicon: chromosome
• Accession: NZ_CP094479
• Organism: Klebsiella pneumoniae strain LXR-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A483FW84
• Locus tag: MST28_RS12960
• Protein ID: WP_040230784.1
• Coordinates: 2637112..2638434 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: MST28_RS12965
• Protein ID: WP_002904790.1
• Coordinates: 2638434..2638700 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST28_RS12945 (2632168)	2632168..2634669	+	2502	WP_243440341.1	fimbria/pilus outer membrane usher protein	-
MST28_RS12950 (2634657)	2634657..2635661	+	1005	WP_032421320.1	fimbrial protein	-
MST28_RS12955 (2635803)	2635803..2637095	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MST28_RS12960 (2637112)	2637112..2638434	-	1323	WP_040230784.1	type II toxin-antitoxin system HipA family toxin	Toxin
MST28_RS12965 (2638434)	2638434..2638700	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MST28_RS12970 (2638965)	2638965..2639291	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
MST28_RS12975 (2639288)	2639288..2639788	-	501	WP_032412207.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MST28_RS12980 (2639766)	2639766..2641145	-	1380	WP_048299445.1	nucleobase:cation symporter-2 family protein	-
MST28_RS12985 (2641491)	2641491..2642645	+	1155	WP_020804972.1	FAD-dependent urate hydroxylase HpxO	-
MST28_RS12990 (2642626)	2642626..2643549	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49231.52 Da
• Isoelectric Point: 7.5357

>T239894 WP_040230784.1 NZ_CP094479:c2638434-2637112 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINTIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T239894 NZ_LS483381:c1234959-1234696 [Streptococcus sobrinus]
ATGTATCAGGTTCGCTATTCCAAGAAAGCCCAGAAGCAAATTAAAAAGTTGGATAAGTCTGTTCAGAGATTCCTCTTTTC
TTGGATTGACAAGCATATAGACGGAAGTGACAACCCTAGACAGTTTGGGAAAGGCCTAAGCGGCAATCATGCCAGAGAGT
GGCGGTATCGTATCGGCGACTATCGCTTGATTTGTGATATTGAGGACGACAAGTTGATCATTCTGGCCTTAGAGTTTGGT
CATAGGAGGGACATCTATAAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT239894 WP_002904790.1 NZ_CP094479:c2638700-2638434 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT239894 NZ_LS483381:c1235181-1234960 [Streptococcus sobrinus]
ATGAGTACAGTAACAGTCAGATTAAACAAAGATGAAGAAGACTTCTTTAAAACCTATGCTCAGATTACAGGAGTCAGTCT
TTCAACCCTCTTTAAAAAGTCGCTGGAAAAGGCCATTGAAGATGAGTATGATTTGAAACTCTATCAAGAGGCCTATCGAG
CCTACCAAGAGGATCCAGAGACTCTTTCTCACGCAGATTTTAAAAAGGAATTAGGTTTCTAA

Structures

Toxin

• AlphaFold DB: A0A483FW84

Antitoxin

• AlphaFold DB: A0A0H3GXD8