Detailed information of TA system TA239881

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 93481..94148
• Replicon: chromosome
• Accession: NZ_CP094479
• Organism: Klebsiella pneumoniae strain LXR-1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: MST28_RS00490
• Protein ID: WP_243440260.1
• Coordinates: 93481..93801 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: E1IS67
• Locus tag: MST28_RS00495
• Protein ID: WP_000052843.1
• Coordinates: 93822..94148 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST28_RS00460 (89164)	89164..89418	-	255	Protein_91	DNA-binding protein	-
MST28_RS00465 (89660)	89660..89947	-	288	WP_016161982.1	SymE family type I addiction module toxin	-
MST28_RS00470 (90261)	90261..90719	-	459	WP_016161981.1	hypothetical protein	-
MST28_RS00475 (90955)	90955..91905	-	951	WP_016161980.1	retron St85 family RNA-directed DNA polymerase	-
MST28_RS00480 (91892)	91892..92446	-	555	WP_243440353.1	hypothetical protein	-
MST28_RS00485 (92513)	92513..92842	-	330	WP_243440259.1	hypothetical protein	-
MST28_RS00490 (93481)	93481..93801	-	321	WP_243440260.1	TA system toxin CbtA family protein	Toxin
MST28_RS00495 (93822)	93822..94148	-	327	WP_000052843.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MST28_RS00500 (94161)	94161..94631	-	471	WP_001275770.1	DNA repair protein RadC	-
MST28_RS00505 (94700)	94700..95521	-	822	WP_243440261.1	DUF932 domain-containing protein	-
MST28_RS00510 (95614)	95614..96624	-	1011	WP_243440262.1	hypothetical protein	-
MST28_RS00515 (96686)	96686..97375	-	690	WP_015703837.1	WYL domain-containing protein	-
MST28_RS00520 (97567)	97567..98460	-	894	WP_000033877.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	89660..105051	15391

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-98)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12113.94 Da
• Isoelectric Point: 5.6773

>T239881 WP_243440260.1 NZ_CP094479:c93801-93481 [Klebsiella pneumoniae]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQRYGLTLNDTPFSDETIIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Nucleotide

• Length: 321 bp

>T239881 NZ_LS483377:283567-283869 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12305.01 Da
• Isoelectric Point: 6.3620

>AT239881 WP_000052843.1 NZ_CP094479:c94148-93822 [Klebsiella pneumoniae]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 327 bp

>AT239881 NZ_LS483377:283221-283526 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Structures

Antitoxin

• AlphaFold DB: A0A345ENE4