Detailed information of TA system TA239880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2878640..2879190
• Replicon: chromosome
• Accession: NZ_CP094470
• Organism: Faecalibacterium sp. I2-3-92

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTP42_RS14190
• Protein ID: WP_097773159.1
• Coordinates: 2878909..2879190 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MTP42_RS14185
• Protein ID: WP_097773160.1
• Coordinates: 2878640..2878912 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP42_RS14170 (MTP42_14170)	2874577..2875857	+	1281	WP_249257624.1	chloride channel protein	-
MTP42_RS14175 (MTP42_14175)	2876226..2878016	+	1791	WP_097771397.1	threonine--tRNA ligase	-
MTP42_RS14180 (MTP42_14180)	2878090..2878470	-	381	WP_249257625.1	hypothetical protein	-
MTP42_RS14185 (MTP42_14185)	2878640..2878912	+	273	WP_097773160.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MTP42_RS14190 (MTP42_14190)	2878909..2879190	+	282	WP_097773159.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MTP42_RS14195 (MTP42_14195)	2879243..2880232	-	990	WP_249257626.1	helix-turn-helix transcriptional regulator	-
MTP42_RS14200 (MTP42_14200)	2880435..2881496	-	1062	WP_005934814.1	tryptophan--tRNA ligase	-
MTP42_RS14215 (MTP42_14215)	2882343..2883947	+	1605	WP_249257627.1	phosphoenolpyruvate carboxykinase (ATP)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11026.56 Da
• Isoelectric Point: 7.0610

>T239880 WP_097773159.1 NZ_CP094470:2878909-2879190 [Faecalibacterium sp. I2-3-92]
MNRDIVWTNQFKKDYKLAQKRHLDIDLLDNIIRTLSHGEPLPEKNRDHALTGDWIGHRECHIQPDWLLIYRIEDNVLVLT
LARTGSHSDLFNK

Nucleotide

• Length: 282 bp

>T239880 NZ_CP094470:2878909-2879190 [Faecalibacterium sp. I2-3-92]
ATGAACCGCGATATCGTCTGGACGAACCAATTCAAGAAGGACTACAAACTTGCTCAAAAACGGCATCTCGACATTGATCT
TCTGGATAATATCATCCGCACCTTATCACATGGGGAACCGCTCCCAGAGAAAAACAGAGACCACGCTTTGACCGGCGATT
GGATCGGCCATCGCGAATGCCACATCCAGCCAGACTGGCTGCTCATCTACCGCATCGAAGACAATGTGCTCGTTTTGACT
TTGGCCCGCACCGGTAGCCACAGCGATTTATTCAACAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10159.63 Da
• Isoelectric Point: 4.8483

>AT239880 WP_097773160.1 NZ_CP094470:2878640-2878912 [Faecalibacterium sp. I2-3-92]
MATTNISIRMDSDLKAQAEALFAELGMNLSTAFNVFVRQSLRDGGIPFEIKMDQPNKETMAAMLEAERIAKDPNVKHYSD
VEEALRELKR

Nucleotide

• Length: 273 bp

>AT239880 NZ_CP094470:2878640-2878912 [Faecalibacterium sp. I2-3-92]
ATGGCAACCACGAATATCAGCATCCGGATGGATTCCGACCTGAAAGCACAGGCAGAAGCCCTGTTTGCAGAGCTGGGCAT
GAATCTTTCCACCGCATTCAACGTCTTTGTCCGTCAGTCTCTGCGTGACGGCGGCATTCCCTTTGAGATCAAGATGGATC
AGCCCAACAAGGAAACCATGGCCGCCATGTTGGAAGCGGAACGCATTGCAAAAGACCCGAATGTAAAGCACTATTCTGAT
GTAGAAGAGGCTCTTCGGGAGTTGAAGCGATGA