Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4722870..4723405 Replicon chromosome
Accession NC_012917
Organism Pectobacterium carotovorum subsp. carotovorum PC1

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag PC1_RS20905 Protein ID WP_015842269.1
Coordinates 4723118..4723405 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag PC1_RS20900 Protein ID WP_010281712.1
Coordinates 4722870..4723121 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PC1_RS20875 4718166..4719299 + 1134 WP_015842264.1 alkylhydroperoxidase domain protein -
PC1_RS20880 4719342..4719965 - 624 WP_015842265.1 LysE family translocator -
PC1_RS20885 4720146..4720850 + 705 WP_015842266.1 SMI1/KNR4 family protein -
PC1_RS20890 4720920..4721675 + 756 WP_015842267.1 thiol:disulfide interchange protein DsbG -
PC1_RS20895 4721710..4722615 - 906 WP_015842268.1 siderophore-interacting protein -
PC1_RS20900 4722870..4723121 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PC1_RS20905 4723118..4723405 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PC1_RS20910 4723514..4724866 - 1353 WP_015842270.1 glutathione-disulfide reductase -
PC1_RS20915 4724995..4725837 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
PC1_RS20920 4726056..4726784 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T23988 WP_015842269.1 NC_012917:4723118-4723405 [Pectobacterium carotovorum subsp. carotovorum PC1]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T23988 NC_012917:4723118-4723405 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAATTACGGGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCGTCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAACGTAGTGGCGTTTATCATCTGGCGAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT23988 WP_010281712.1 NC_012917:4722870-4723121 [Pectobacterium carotovorum subsp. carotovorum PC1]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT23988 NC_012917:4722870-4723121 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGCCGAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAATTGAAAAAGAACCCGATGGCGACGGTCAATGCTGG
CGACGGTCTACCTGTCGCTATTTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGCAAAAACCAGCCACTGGTTGACGTGGATTTGGAT
AGTTTCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References