Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Tad-HTH_37
Location 1238909..1239546 Replicon chromosome
Accession NZ_CP094470
Organism Faecalibacterium sp. I2-3-92

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag MTP42_RS06115 Protein ID WP_156057749.1
Coordinates 1238909..1239268 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTP42_RS06120 Protein ID WP_098922624.1
Coordinates 1239265..1239546 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP42_RS06090 (MTP42_06090) 1234372..1236270 + 1899 WP_097770727.1 nucleoside-diphosphate sugar epimerase/dehydratase -
MTP42_RS06095 (MTP42_06095) 1236445..1237740 + 1296 WP_035394396.1 diaminopimelate decarboxylase -
MTP42_RS06100 (MTP42_06100) 1237769..1238167 + 399 WP_249258192.1 hypothetical protein -
MTP42_RS06105 (MTP42_06105) 1238314..1238655 + 342 WP_005933882.1 hypothetical protein -
MTP42_RS06115 (MTP42_06115) 1238909..1239268 + 360 WP_156057749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTP42_RS06120 (MTP42_06120) 1239265..1239546 + 282 WP_098922624.1 helix-turn-helix transcriptional regulator Antitoxin
MTP42_RS06125 (MTP42_06125) 1239713..1240423 + 711 WP_005933880.1 UMP kinase -
MTP42_RS06130 (MTP42_06130) 1240511..1241065 + 555 WP_005933879.1 ribosome recycling factor -
MTP42_RS06135 (MTP42_06135) 1241178..1241891 + 714 WP_035394393.1 polyprenyl diphosphate synthase -
MTP42_RS06140 (MTP42_06140) 1241922..1242782 + 861 WP_005933875.1 phosphatidate cytidylyltransferase -
MTP42_RS06145 (MTP42_06145) 1242799..1243950 + 1152 WP_099357205.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-82)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13724.83 Da        Isoelectric Point: 9.5800

>T239879 WP_156057749.1 NZ_CP094470:1238909-1239268 [Faecalibacterium sp. I2-3-92]
VQEYEIEFYDKADGSEPAKEFILALDAKMRAKVVRTVGLLREEGPSLREPYSKHLEDGIFEIRTKFGSDITRVLYFFVIG
RRIILTNGFVKKTQKTPASEIALAKQYRADYLSRKECSK

Download         Length: 360 bp

>T239879 NZ_LS483377:c125078-123756 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCAGGTCTGGATGAATGGTGTGGAAGTCGCACTTTGGGATGATGTCCGGAACGGGTCATCCCGGTTGTC
GTATGTCAGCCAGTGGATCAGCTCGCCCCAGTCCCGACCGTTGTCGCTCTCTCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCGCCATACGCAACCGGATCCGCGACCGG
TTCGCCACGCGCGGCAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGGGATTGTGTCGGCGCAGTGCAGCTGTTGCC
GCCAGCGCGTCCACCCGAAGACATCCAGCAGATCACGTGCGAGGTGTTGGACGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGATGCATTCCGCATTTCCATCGCCGGTGCGCAGGAAAAG
ACCGGTCTTCTGCTGCATGCTGGCAAATGGTGCATTCCTACCGGCAACACACCATCCACTCACATCTTCAAGCTGCCGCT
TGGCATTGTTGGCAACATGCGGGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCCT
TTGATATCCCCGTGGCCGAGACGCAGATGGGCCGCTTCAACGACCAACGTGCTCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGCCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGTCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCCGGTATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGCCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCAGGGGACCCAATCAACT
CGATCCACGAAACGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCGACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAG
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGACTTCCCCTCAAACGTGTCCGAACCGATTTTCAACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10423.93 Da        Isoelectric Point: 6.3424

>AT239879 WP_098922624.1 NZ_CP094470:1239265-1239546 [Faecalibacterium sp. I2-3-92]
MTNFNDFLNEQMKDPEFKAEWDALDPEFAVIEAILAARKKSGLTQQQLSERTGIAQTDISKLERGNGNPSLRTLQRLAAG
MGMRVKIEFVPAK

Download         Length: 282 bp

>AT239879 NZ_LS483377:c125339-125082 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACAGTGAGGACAGCCCAACAACTTGCGCCCCTGATGCGTGCTTTCCGGCGCCAGGCGGGCCT
GAGCCAGGCTCAGCTGGCGGAGCGACTCGGGATCAGCCGCCAGGCAGTGGGCGCGCTGGAACGCGACCCTGCATCGGCAA
GTTTTGAACGCCTGATGCGGATCTGGGCGGTGCTGGGTCTGGAGGTCAGCCTCCAGCAACGAAGTCCCCAGGAGAACACG
TCGTCATTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References