Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1624466..1625175 | Replicon | chromosome |
| Accession | NZ_CP094468 | ||
| Organism | Faecalibacterium sp. I3-3-89 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MTP38_RS07550 | Protein ID | WP_112114942.1 |
| Coordinates | 1624466..1624657 (+) | Length | 64 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MTP38_RS07555 | Protein ID | WP_015538062.1 |
| Coordinates | 1624798..1625175 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTP38_RS07535 (MTP38_07535) | 1620403..1621428 | - | 1026 | WP_249233157.1 | plasmid recombination protein | - |
| MTP38_RS07540 (MTP38_07540) | 1622458..1623876 | - | 1419 | WP_249233158.1 | Eco57I restriction-modification methylase domain-containing protein | - |
| MTP38_RS07545 (MTP38_07545) | 1624050..1624352 | + | 303 | WP_249233159.1 | helix-turn-helix transcriptional regulator | - |
| MTP38_RS07550 (MTP38_07550) | 1624466..1624657 | + | 192 | WP_112114942.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MTP38_RS07555 (MTP38_07555) | 1624798..1625175 | + | 378 | WP_015538062.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MTP38_RS07560 (MTP38_07560) | 1625230..1626114 | + | 885 | WP_249233160.1 | hypothetical protein | - |
| MTP38_RS07565 (MTP38_07565) | 1626480..1628120 | - | 1641 | WP_249233161.1 | chaperonin GroEL | - |
| MTP38_RS07570 (MTP38_07570) | 1628175..1628459 | - | 285 | WP_015563875.1 | co-chaperone GroES | - |
| MTP38_RS07575 (MTP38_07575) | 1628669..1629649 | - | 981 | WP_249233162.1 | diacylglycerol kinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL | 1617273..1628459 | 11186 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 64 a.a. Molecular weight: 7076.36 Da Isoelectric Point: 10.7682
>T239878 WP_112114942.1 NZ_CP094468:1624466-1624657 [Faecalibacterium sp. I3-3-89]
MPMTPKQMIRLLEQNGFVLVSANGSHYKYHNPTTNKTTVVPFHAKDLKPGTEKNILKLAGLKK
MPMTPKQMIRLLEQNGFVLVSANGSHYKYHNPTTNKTTVVPFHAKDLKPGTEKNILKLAGLKK
Download Length: 192 bp
>T239878 NZ_LS483375:383729-384496 [Streptococcus gordonii]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCAGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCTTACAGGAA
AAGTATGGAAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACAAGGTTATCATTTGTTAATCGAGGGCACCTTGAGAACAACAGAAGTTCCTAGAAAAACGGCACAATTATTGATAACTA
AAGGATATCAAGTCTCACTTGCACTAATAGCGACCAAGCCAGAATTGTCCTATCTCAGTACTTTGATACGTTATGAGGAG
CTCTACGCCATAGATTCTAGTCAAGCTAGAGCAACTCCTAAAGCACACCATGATGGAATTGTAGAACATATGGTTGATAA
CTTACGGGAGTTAGAAAATGATAAACTTTTTAGACAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGATCAAATCTCAGCAGCAGAAGTTCTACAAGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAGAGAGATGGGGGGAATTAATAAGTGA
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCAGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCTTACAGGAA
AAGTATGGAAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACAAGGTTATCATTTGTTAATCGAGGGCACCTTGAGAACAACAGAAGTTCCTAGAAAAACGGCACAATTATTGATAACTA
AAGGATATCAAGTCTCACTTGCACTAATAGCGACCAAGCCAGAATTGTCCTATCTCAGTACTTTGATACGTTATGAGGAG
CTCTACGCCATAGATTCTAGTCAAGCTAGAGCAACTCCTAAAGCACACCATGATGGAATTGTAGAACATATGGTTGATAA
CTTACGGGAGTTAGAAAATGATAAACTTTTTAGACAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGATCAAATCTCAGCAGCAGAAGTTCTACAAGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAGAGAGATGGGGGGAATTAATAAGTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 14002.94 Da Isoelectric Point: 4.1445
>AT239878 WP_015538062.1 NZ_CP094468:1624798-1625175 [Faecalibacterium sp. I3-3-89]
MNAIFYPAIFHPEETGYSVEIPDIEGCFTQGDTMDEAVRMAQDAIGLMLEDCKVCPEPSVPSALHVDPEDFVVMVPFDME
EYEKRYRPVKKTLSIPGWLNDAAESAHINFSGVLQDALKEKLHLA
MNAIFYPAIFHPEETGYSVEIPDIEGCFTQGDTMDEAVRMAQDAIGLMLEDCKVCPEPSVPSALHVDPEDFVVMVPFDME
EYEKRYRPVKKTLSIPGWLNDAAESAHINFSGVLQDALKEKLHLA
Download Length: 378 bp
>AT239878 NZ_LS483375:383253-383729 [Streptococcus gordonii]
ATGATAGGAGAAAATATTAAAGCGTTACGTAAAACACATGATCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAACGGGACAAGTTCAATTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCCTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTGGAAGATTACCAGCTCACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTGCTGAACACGAAGATTTATCTTGTGGGGACTTTTGATG
AAGTAGAGCGATATAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA
ATGATAGGAGAAAATATTAAAGCGTTACGTAAAACACATGATCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAACGGGACAAGTTCAATTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCCTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTGGAAGATTACCAGCTCACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTGCTGAACACGAAGATTTATCTTGTGGGGACTTTTGATG
AAGTAGAGCGATATAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|