Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1210112..1210740 Replicon chromosome
Accession NZ_CP094468
Organism Faecalibacterium sp. I3-3-89

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTP38_RS05590 Protein ID WP_249234522.1
Coordinates 1210339..1210740 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTP38_RS05585 Protein ID WP_249234521.1
Coordinates 1210112..1210342 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP38_RS05575 (MTP38_05575) 1205153..1205581 + 429 WP_249234519.1 hypothetical protein -
MTP38_RS05580 (MTP38_05580) 1205900..1209883 + 3984 WP_249234520.1 metallophosphoesterase -
MTP38_RS05585 (MTP38_05585) 1210112..1210342 + 231 WP_249234521.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MTP38_RS05590 (MTP38_05590) 1210339..1210740 + 402 WP_249234522.1 type II toxin-antitoxin system VapC family toxin Toxin
MTP38_RS05595 (MTP38_05595) 1211483..1212025 + 543 WP_249234702.1 hypothetical protein -
MTP38_RS05600 (MTP38_05600) 1212175..1212492 + 318 WP_249234523.1 DUF3847 domain-containing protein -
MTP38_RS05605 (MTP38_05605) 1212502..1212690 - 189 WP_249234524.1 hypothetical protein -
MTP38_RS05610 (MTP38_05610) 1212707..1213519 - 813 WP_055192377.1 PD-(D/E)XK nuclease family transposase -
MTP38_RS05615 (MTP38_05615) 1213613..1213747 + 135 Protein_1087 hypothetical protein -
MTP38_RS05620 (MTP38_05620) 1213767..1214021 + 255 WP_249234664.1 TnpV protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1203269..1214021 10752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(9-49)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15224.52 Da        Isoelectric Point: 4.9914

>T239877 WP_249234522.1 NZ_CP094468:1210339-1210740 [Faecalibacterium sp. I3-3-89]
MKYMLDTNICIYAMKHKPPEAIKNFLMHDPDDMCISAITYGELMHGVEKSQAVERNRVAVTLFLSSIDILSFDHYAAEEY
GKVRADLERKGTPIGPMDMLIAAHARSEGLILVTNNTREFFRVEDLEVEDWTK

Download         Length: 402 bp

>T239877 NZ_LS483374:c1596002-1595823 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8610.77 Da        Isoelectric Point: 4.5702

>AT239877 WP_249234521.1 NZ_CP094468:1210112-1210342 [Faecalibacterium sp. I3-3-89]
MMTAKLFENGRSQAVRLPKECRFNGDEVAISKVGDAVILLPKENRWSGFLSSLDLFSDDFMSEGREQPAMQERESL

Download         Length: 231 bp

>AT239877 NZ_LS483374:c1595786-1595334 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References