Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 774599..775226 Replicon chromosome
Accession NZ_CP094468
Organism Faecalibacterium sp. I3-3-89

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MTP38_RS03680 Protein ID WP_249234300.1
Coordinates 774599..774796 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MTP38_RS03685 Protein ID WP_249234301.1
Coordinates 774816..775226 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP38_RS03655 (MTP38_03655) 770555..771553 + 999 WP_158396431.1 beta-methylgalactoside transporter -
MTP38_RS03660 (MTP38_03660) 772065..772379 + 315 WP_227620354.1 hypothetical protein -
MTP38_RS03665 (MTP38_03665) 772479..773849 - 1371 WP_227620355.1 NCS2 family permease -
MTP38_RS03675 (MTP38_03675) 774326..774502 - 177 WP_249234299.1 hypothetical protein -
MTP38_RS03680 (MTP38_03680) 774599..774796 + 198 WP_249234300.1 type II toxin-antitoxin system HicA family toxin Toxin
MTP38_RS03685 (MTP38_03685) 774816..775226 + 411 WP_249234301.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MTP38_RS03690 (MTP38_03690) 775484..775717 - 234 WP_227620358.1 methylenetetrahydrofolate dehydrogenase -
MTP38_RS03695 (MTP38_03695) 775784..776599 - 816 WP_249234302.1 TatD family hydrolase -
MTP38_RS03700 (MTP38_03700) 776596..777555 - 960 WP_249234303.1 DMT family transporter -
MTP38_RS03705 (MTP38_03705) 777559..779556 - 1998 WP_249234304.1 methionine--tRNA ligase -
MTP38_RS03710 (MTP38_03710) 779911..780213 - 303 WP_158400089.1 Dabb family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7464.50 Da        Isoelectric Point: 10.3434

>T239876 WP_249234300.1 NZ_CP094468:774599-774796 [Faecalibacterium sp. I3-3-89]
VKSYSSREVIKALKADGWYEVNCVGSHHQYKHPTKPGRVTVKDPDKDIPRATLNRIEQQSGLKFR

Download         Length: 198 bp

>T239876 NZ_LS483374:c1574693-1574439 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14937.93 Da        Isoelectric Point: 4.3751

>AT239876 WP_249234301.1 NZ_CP094468:774816-775226 [Faecalibacterium sp. I3-3-89]
MKKNLPDRYFYPAVFIYEDGQEIAVDFPDLGVATSGTSEDDALLSARELLGCVMCGLEEDGEPIPAPSALSDIHPKDNER
VVLVDAYMPSVRLASVNRSVNRTVTLPAWLNAAALERNVNFSQVLQDALKHQLHLA

Download         Length: 411 bp

>AT239876 NZ_LS483374:c1574951-1574697 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References