Detailed information of TA system TA239875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 168567..169126
• Replicon: chromosome
• Accession: NZ_CP094467
• Organism: Faecalibacterium sp. I4-1-79

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTP36_RS00820
• Protein ID: WP_118658513.1
• Coordinates: 168836..169126 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MTP36_RS00815
• Protein ID: WP_112091363.1
• Coordinates: 168567..168839 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP36_RS00790 (MTP36_00790)	163968..164777	+	810	WP_006735344.1	gluconate 5-dehydrogenase	-
MTP36_RS00795 (MTP36_00795)	164875..165219	+	345	WP_249252810.1	cupin domain-containing protein	-
MTP36_RS00800 (MTP36_00800)	165263..165898	+	636	WP_015537141.1	RpiB/LacA/LacB family sugar-phosphate isomerase	-
MTP36_RS00805 (MTP36_00805)	165914..166330	+	417	WP_015537140.1	DUF1622 domain-containing protein	-
MTP36_RS00810 (MTP36_00810)	166568..168307	+	1740	WP_117554668.1	ammonium transporter	-
MTP36_RS00815 (MTP36_00815)	168567..168839	+	273	WP_112091363.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MTP36_RS00820 (MTP36_00820)	168836..169126	+	291	WP_118658513.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MTP36_RS00825 (MTP36_00825)	169203..170987	-	1785	WP_249252812.1	threonine--tRNA ligase	-
MTP36_RS00830 (MTP36_00830)	171070..171255	-	186	WP_143406238.1	hypothetical protein	-
MTP36_RS00835 (MTP36_00835)	171470..172390	+	921	WP_097779343.1	nucleotidyltransferase	-
MTP36_RS00840 (MTP36_00840)	172474..172929	-	456	WP_249252814.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-88)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11123.96 Da
• Isoelectric Point: 9.1748

>T239875 WP_118658513.1 NZ_CP094467:168836-169126 [Faecalibacterium sp. I4-1-79]
MRETKLTIIPTTQFRKDYKLARKRGLKIELLQDVIACLAMGEPLPEKNRDHALTGDWVGHRECHIQPDWLLVYRVQNDVL
VLTLTRTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T239875 NZ_LS483374:c1113105-1112851 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10071.49 Da
• Isoelectric Point: 4.6677

>AT239875 WP_112091363.1 NZ_CP094467:168567-168839 [Faecalibacterium sp. I4-1-79]
MATTNVSIRMDADLKAQADALFAELGMNLSTAFNIFVRQSLREGGIPFEIRTERPNKETVAAMLEAEHIAADPKAKKYRD
LDELFADLEK

Nucleotide

• Length: 273 bp

>AT239875 NZ_LS483374:c1113349-1113107 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA