Detailed information of TA system TA239874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2324994..2325559
• Replicon: chromosome
• Accession: NZ_CP094466
• Organism: Faecalibacterium sp. I4-3-84

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTP41_RS11365
• Protein ID: WP_118724380.1
• Coordinates: 2324994..2325284 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7H6P4
• Locus tag: MTP41_RS11370
• Protein ID: WP_005924829.1
• Coordinates: 2325281..2325559 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP41_RS11335 (MTP41_11335)	2321169..2321510	+	342	WP_003020223.1	hypothetical protein	-
MTP41_RS11340 (MTP41_11340)	2321510..2322223	+	714	WP_249235549.1	antirestriction protein ArdA	-
MTP41_RS11345 (MTP41_11345)	2322348..2322746	+	399	WP_117536001.1	PcfB family protein	-
MTP41_RS11350 (MTP41_11350)	2322733..2323596	+	864	Protein_2210	type IV secretory system conjugative DNA transfer family protein	-
MTP41_RS11355 (MTP41_11355)	2323721..2324650	+	930	Protein_2211	DUF4368 domain-containing protein	-
MTP41_RS11360 (MTP41_11360)	2324677..2324784	+	108	Protein_2212	TnpV protein	-
MTP41_RS11365 (MTP41_11365)	2324994..2325284	-	291	WP_118724380.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MTP41_RS11370 (MTP41_11370)	2325281..2325559	-	279	WP_005924829.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MTP41_RS11375 (MTP41_11375)	2325686..2326084	+	399	WP_118724379.1	cysteine-rich VLP domain-containing protein	-
MTP41_RS11380 (MTP41_11380)	2326198..2326932	+	735	WP_118724378.1	phage replisome organizer N-terminal domain-containing protein	-
MTP41_RS11385 (MTP41_11385)	2326929..2327792	+	864	WP_118724377.1	ATP-binding protein	-
MTP41_RS11390 (MTP41_11390)	2327836..2328030	+	195	WP_118724376.1	transposon-encoded TnpW family protein	-
MTP41_RS11395 (MTP41_11395)	2328108..2328473	+	366	WP_118724375.1	hypothetical protein	-
MTP41_RS11400 (MTP41_11400)	2328530..2329843	-	1314	WP_117470902.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2322228..2359614	37386

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11158.96 Da
• Isoelectric Point: 7.9002

>T239874 WP_118724380.1 NZ_CP094466:c2325284-2324994 [Faecalibacterium sp. I4-3-84]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWACHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T239874 NZ_LS483374:c1021729-1020968 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10247.66 Da
• Isoelectric Point: 4.4692

>AT239874 WP_005924829.1 NZ_CP094466:c2325559-2325281 [Faecalibacterium sp. I4-3-84]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Nucleotide

• Length: 279 bp

>AT239874 NZ_LS483374:c1022205-1021729 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACAGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1M4XB19