Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
| Location | 586668..587233 | Replicon | chromosome |
| Accession | NZ_CP094466 | ||
| Organism | Faecalibacterium sp. I4-3-84 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | C7H6P5 |
| Locus tag | MTP41_RS02920 | Protein ID | WP_002596328.1 |
| Coordinates | 586943..587233 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | C7H6P4 |
| Locus tag | MTP41_RS02915 | Protein ID | WP_005924829.1 |
| Coordinates | 586668..586946 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTP41_RS02870 (MTP41_02870) | 581770..582147 | - | 378 | WP_005927690.1 | TnpV protein | - |
| MTP41_RS02875 (MTP41_02875) | 582107..582379 | - | 273 | WP_002593556.1 | helix-turn-helix domain-containing protein | - |
| MTP41_RS02880 (MTP41_02880) | 582537..582695 | - | 159 | WP_249236153.1 | Maff2 family protein | - |
| MTP41_RS02885 (MTP41_02885) | 582827..583645 | - | 819 | Protein_558 | TraG/TraD/VirD4 family protein | - |
| MTP41_RS02890 (MTP41_02890) | 583739..584104 | - | 366 | WP_014080225.1 | hypothetical protein | - |
| MTP41_RS02895 (MTP41_02895) | 584182..584376 | - | 195 | WP_005933543.1 | transposon-encoded TnpW family protein | - |
| MTP41_RS02900 (MTP41_02900) | 584420..585283 | - | 864 | WP_005933545.1 | ATP-binding protein | - |
| MTP41_RS02905 (MTP41_02905) | 585280..586029 | - | 750 | WP_005933547.1 | phage replisome organizer N-terminal domain-containing protein | - |
| MTP41_RS02910 (MTP41_02910) | 586143..586541 | - | 399 | WP_005933550.1 | cysteine-rich VLP domain-containing protein | - |
| MTP41_RS02915 (MTP41_02915) | 586668..586946 | + | 279 | WP_005924829.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MTP41_RS02920 (MTP41_02920) | 586943..587233 | + | 291 | WP_002596328.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MTP41_RS02925 (MTP41_02925) | 587341..588786 | - | 1446 | WP_249236154.1 | MobQ family relaxase | - |
| MTP41_RS02930 (MTP41_02930) | 588974..589264 | - | 291 | WP_055214737.1 | DUF3847 domain-containing protein | - |
| MTP41_RS02935 (MTP41_02935) | 589293..589754 | - | 462 | WP_009296689.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| MTP41_RS02940 (MTP41_02940) | 589765..590217 | - | 453 | WP_055214735.1 | hypothetical protein | - |
| MTP41_RS02945 (MTP41_02945) | 590321..590734 | - | 414 | WP_055214733.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| MTP41_RS02950 (MTP41_02950) | 591576..591950 | - | 375 | WP_055214731.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11112.87 Da Isoelectric Point: 8.0630
>T239872 WP_002596328.1 NZ_CP094466:586943-587233 [Faecalibacterium sp. I4-3-84]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK
Download Length: 291 bp
>T239872 NZ_LS483368:857654-857914 [Streptococcus equi subsp. zooepidemicus]
ATGTATCATATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAACTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGCATTTAGAGGGAACAGATAACCCACGCGCAAATGGTAAGGGTTTGGCAGGAAATCATGCTAATGAAT
GGCGTTATCGTATTGGTGATTATCGGCTTATTTGTGATATTCAAGATGATAAGATGGTTATTTTAGCGCTTGAGTTTGGG
CATAGGCGAGATGTTTATTAA
ATGTATCATATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAACTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGCATTTAGAGGGAACAGATAACCCACGCGCAAATGGTAAGGGTTTGGCAGGAAATCATGCTAATGAAT
GGCGTTATCGTATTGGTGATTATCGGCTTATTTGTGATATTCAAGATGATAAGATGGTTATTTTAGCGCTTGAGTTTGGG
CATAGGCGAGATGTTTATTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10247.66 Da Isoelectric Point: 4.4692
>AT239872 WP_005924829.1 NZ_CP094466:586668-586946 [Faecalibacterium sp. I4-3-84]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR
Download Length: 279 bp
>AT239872 NZ_LS483368:857431-857652 [Streptococcus equi subsp. zooepidemicus]
ATGGGTACAGTTACTATCAGATTAAATCAAGAGGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCTCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAACTCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCGGATTTTAAGAAAGAGCTAGGCTTATAA
ATGGGTACAGTTACTATCAGATTAAATCAAGAGGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCTCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAACTCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCGGATTTTAAGAAAGAGCTAGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XBM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M4XB19 |