Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1797156..1797721 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MRS60_RS24890 Protein ID WP_131949192.1
Coordinates 1797350..1797721 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1K1SS38
Locus tag MRS60_RS24885 Protein ID WP_072444647.1
Coordinates 1797156..1797353 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS24860 (MRS60_24860) 1792300..1792755 - 456 WP_034181777.1 RbsD/FucU family protein -
MRS60_RS24865 (MRS60_24865) 1792833..1793225 - 393 WP_105391026.1 nuclear transport factor 2 family protein -
MRS60_RS24870 (MRS60_24870) 1793444..1794997 - 1554 WP_105391105.1 galactarate dehydratase -
MRS60_RS24875 (MRS60_24875) 1795228..1796142 + 915 WP_034181775.1 5-dehydro-4-deoxyglucarate dehydratase -
MRS60_RS24880 (MRS60_24880) 1796342..1796893 - 552 WP_243565724.1 hypothetical protein -
MRS60_RS24885 (MRS60_24885) 1797156..1797353 + 198 WP_072444647.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MRS60_RS24890 (MRS60_24890) 1797350..1797721 + 372 WP_131949192.1 type II toxin-antitoxin system VapC family toxin Toxin
MRS60_RS24895 (MRS60_24895) 1797855..1799432 - 1578 WP_131949191.1 aldehyde dehydrogenase (NADP(+)) -
MRS60_RS24900 (MRS60_24900) 1799684..1801060 + 1377 WP_034181771.1 MFS transporter -
MRS60_RS24905 (MRS60_24905) 1801135..1801860 - 726 WP_072444600.1 site-2 protease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13433.45 Da        Isoelectric Point: 6.2125

>T239869 WP_131949192.1 NZ_CP094460:1797350-1797721 [Burkholderia pyrrocinia]
MILVDTSVWIDHLRAGDAALTTLLEAERVLIHPFVVGELSLGSLRDRQTVLDALRDLPAATSATDDEVQRMIDVVPLHGL
GIGYVDAHLLASVRLTSGSKLWTRDRRLLAATDRLQLAAHPAH

Download         Length: 372 bp

>T239869 NZ_LS483365:c2542811-2542545 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7064.14 Da        Isoelectric Point: 10.6826

>AT239869 WP_072444647.1 NZ_CP094460:1797156-1797353 [Burkholderia pyrrocinia]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLEPVPRRPSEPA

Download         Length: 198 bp

>AT239869 NZ_LS483365:c2543068-2542811 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1K1SS38

References