Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1252082..1252605 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name relE Uniprot ID A0A2S8ISR8
Locus tag MRS60_RS22480 Protein ID WP_034180530.1
Coordinates 1252339..1252605 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2S8ISV9
Locus tag MRS60_RS22475 Protein ID WP_034180529.1
Coordinates 1252082..1252342 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS22445 (MRS60_22445) 1247439..1248647 - 1209 WP_131948430.1 acetate/propionate family kinase -
MRS60_RS22450 (MRS60_22450) 1248658..1249629 - 972 WP_034180525.1 phosphate acetyltransferase -
MRS60_RS22455 (MRS60_22455) 1249775..1250644 + 870 WP_034180526.1 ATP synthase F1 subunit gamma -
MRS60_RS22460 (MRS60_22460) 1250656..1251114 + 459 WP_034180527.1 ATP synthase F1 subunit epsilon -
MRS60_RS22465 (MRS60_22465) 1251138..1251356 - 219 WP_006480837.1 DUF1653 domain-containing protein -
MRS60_RS22470 (MRS60_22470) 1251414..1251857 - 444 WP_034180528.1 GNAT family N-acetyltransferase -
MRS60_RS22475 (MRS60_22475) 1252082..1252342 + 261 WP_034180529.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MRS60_RS22480 (MRS60_22480) 1252339..1252605 + 267 WP_034180530.1 Txe/YoeB family addiction module toxin Toxin
MRS60_RS22485 (MRS60_22485) 1252907..1253530 + 624 WP_243566711.1 HAD hydrolase-like protein -
MRS60_RS22490 (MRS60_22490) 1253922..1254500 + 579 WP_243566712.1 DUF4142 domain-containing protein -
MRS60_RS22495 (MRS60_22495) 1254642..1255241 - 600 WP_243566713.1 GNAT family protein -
MRS60_RS22500 (MRS60_22500) 1255298..1256212 - 915 WP_243566714.1 LysR family transcriptional regulator -
MRS60_RS22505 (MRS60_22505) 1256322..1257560 + 1239 WP_034180535.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10478.81 Da        Isoelectric Point: 7.9861

>T239867 WP_034180530.1 NZ_CP094460:1252339-1252605 [Burkholderia pyrrocinia]
MSVRRVLVTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYE

Download         Length: 267 bp

>T239867 NZ_LS483365:c2485958-2485692 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9656.98 Da        Isoelectric Point: 6.8791

>AT239867 WP_034180529.1 NZ_CP094460:1252082-1252342 [Burkholderia pyrrocinia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKVHK
LAEDGE

Download         Length: 261 bp

>AT239867 NZ_LS483365:c2486209-2485958 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S8ISR8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8ISV9

References