Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1180659..1181314 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MRS60_RS22120 Protein ID WP_243566689.1
Coordinates 1180659..1181078 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2S8IH63
Locus tag MRS60_RS22125 Protein ID WP_034180974.1
Coordinates 1181075..1181314 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS22095 (MRS60_22095) 1175724..1176302 + 579 WP_243566686.1 hypothetical protein -
MRS60_RS22100 (MRS60_22100) 1176299..1177138 + 840 WP_243566687.1 hypothetical protein -
MRS60_RS22105 (MRS60_22105) 1177630..1178484 + 855 WP_243566688.1 restriction endonuclease -
MRS60_RS22110 (MRS60_22110) 1178863..1178997 - 135 WP_021158165.1 entericidin A/B family lipoprotein -
MRS60_RS22115 (MRS60_22115) 1179231..1180526 + 1296 WP_034180473.1 aspartate carbamoyltransferase -
MRS60_RS22120 (MRS60_22120) 1180659..1181078 - 420 WP_243566689.1 PIN domain-containing protein Toxin
MRS60_RS22125 (MRS60_22125) 1181075..1181314 - 240 WP_034180974.1 Arc family DNA-binding protein Antitoxin
MRS60_RS22130 (MRS60_22130) 1181625..1183865 + 2241 WP_243566690.1 TonB-dependent siderophore receptor -
MRS60_RS22135 (MRS60_22135) 1183869..1184624 + 756 WP_243566691.1 tetratricopeptide repeat protein -
MRS60_RS22140 (MRS60_22140) 1184621..1185304 + 684 WP_243566692.1 Fe2+-dependent dioxygenase -
MRS60_RS22145 (MRS60_22145) 1185386..1185808 - 423 WP_034180480.1 amino acid-binding protein -
MRS60_RS22150 (MRS60_22150) 1186014..1186253 + 240 WP_034180481.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15309.75 Da        Isoelectric Point: 6.9861

>T239866 WP_243566689.1 NZ_CP094460:c1181078-1180659 [Burkholderia pyrrocinia]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAVLPEGRRREWLHQSIERRVVPLFRGRILPFDD
AASKAYASLRARARAAGSAIAPVDCFIAATAEANGLIVATRDVAPFEAVGLRVIDPWAR

Download         Length: 420 bp

>T239866 NZ_LS483365:c2220837-2220733 [Staphylococcus aureus subsp. aureus NCTC 8325]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8707.89 Da        Isoelectric Point: 5.6864

>AT239866 WP_034180974.1 NZ_CP094460:c1181314-1181075 [Burkholderia pyrrocinia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVDFDVQRDKTSTDPMSFE

Download         Length: 240 bp

>AT239866 NZ_LS483365:2220639-2220677 [Staphylococcus aureus subsp. aureus NCTC 8325]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8IH63

References