Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 674637..675270 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MRS60_RS19875 Protein ID WP_243566479.1
Coordinates 674857..675270 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MRS60_RS19870 Protein ID WP_034179540.1
Coordinates 674637..674870 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS19860 (MRS60_19860) 671305..673605 + 2301 WP_243566478.1 ATP-dependent DNA helicase -
MRS60_RS19865 (MRS60_19865) 673705..674475 - 771 WP_072436791.1 IclR family transcriptional regulator C-terminal domain-containing protein -
MRS60_RS19870 (MRS60_19870) 674637..674870 + 234 WP_034179540.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MRS60_RS19875 (MRS60_19875) 674857..675270 + 414 WP_243566479.1 PIN domain-containing protein Toxin
MRS60_RS19880 (MRS60_19880) 675436..676047 + 612 WP_243566480.1 hypothetical protein -
MRS60_RS19885 (MRS60_19885) 676176..677477 - 1302 WP_034179537.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
MRS60_RS19890 (MRS60_19890) 677682..678989 - 1308 WP_243566481.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15181.37 Da        Isoelectric Point: 5.5984

>T239863 WP_243566479.1 NZ_CP094460:674857-675270 [Burkholderia pyrrocinia]
MSGIESAKSFVDSNVVLYLLSGDETKANRAEALFLRRPTISVQVLNEVASVCSRKLRMPWSDVAQFLEPIRSLCHVVPVT
IDTHDLARRLAERHGLSFYDACIVAAASLEGCEYLYTEDMHDGLRVDGGPVLRNPFA

Download         Length: 414 bp

>T239863 NZ_LS483365:c2046390-2046214 [Staphylococcus aureus subsp. aureus NCTC 8325]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8837.08 Da        Isoelectric Point: 8.8306

>AT239863 WP_034179540.1 NZ_CP094460:674637-674870 [Burkholderia pyrrocinia]
MQVAKWGNSLAVRLPATVVEALELREGDDIEIVVDSPRVFAVSRKPRADELLQRLRRFRGKLPADFKFSRDDANERD

Download         Length: 234 bp

>AT239863 NZ_LS483365:2046091-2046146 [Staphylococcus aureus subsp. aureus NCTC 8325]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References