Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1813818..1814494 Replicon chromosome
Accession NZ_CP094459
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag MRS60_RS08440 Protein ID WP_243565581.1
Coordinates 1814078..1814494 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag MRS60_RS08435 Protein ID WP_175749502.1
Coordinates 1813818..1814081 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS08420 (MRS60_08420) 1809373..1811625 + 2253 WP_243565579.1 TonB-dependent siderophore receptor -
MRS60_RS08425 (MRS60_08425) 1811712..1812551 + 840 WP_243565580.1 formyltransferase family protein -
MRS60_RS08430 (MRS60_08430) 1812551..1813567 + 1017 WP_034184277.1 GNAT family N-acetyltransferase -
MRS60_RS08435 (MRS60_08435) 1813818..1814081 + 264 WP_175749502.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MRS60_RS08440 (MRS60_08440) 1814078..1814494 + 417 WP_243565581.1 PIN domain-containing protein Toxin
MRS60_RS08445 (MRS60_08445) 1814543..1815448 - 906 WP_243565582.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
MRS60_RS08450 (MRS60_08450) 1815417..1816490 - 1074 WP_243565583.1 type IV toxin-antitoxin system AbiEi family antitoxin -
MRS60_RS08455 (MRS60_08455) 1816834..1817997 + 1164 WP_243565584.1 M20 aminoacylase family protein -
MRS60_RS08460 (MRS60_08460) 1818167..1818706 + 540 WP_034184279.1 outer membrane protein assembly factor BamE -
MRS60_RS08465 (MRS60_08465) 1818834..1819079 + 246 WP_131947032.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14564.71 Da        Isoelectric Point: 7.8895

>T239861 WP_243565581.1 NZ_CP094459:1814078-1814494 [Burkholderia pyrrocinia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAVRGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T239861 NZ_LS483365:1841432-1841527 [Staphylococcus aureus subsp. aureus NCTC 8325]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9702.95 Da        Isoelectric Point: 4.6310

>AT239861 WP_175749502.1 NZ_CP094459:1813818-1814081 [Burkholderia pyrrocinia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLADRPAVIESGRFDLSGDAG
APTESGR

Download         Length: 264 bp

>AT239861 NZ_LS483365:c1841614-1841555 [Staphylococcus aureus subsp. aureus NCTC 8325]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References