Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 176660..177306 Replicon chromosome
Accession NZ_CP094459
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MRS60_RS00770 Protein ID WP_034183868.1
Coordinates 176896..177306 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag MRS60_RS00765 Protein ID WP_243565079.1
Coordinates 176660..176896 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS00745 (MRS60_00745) 172596..173690 - 1095 WP_243565587.1 ADP-heptose--LPS heptosyltransferase -
MRS60_RS00750 (MRS60_00750) 173687..175390 - 1704 WP_243565078.1 thiamine pyrophosphate-binding protein -
MRS60_RS00755 (MRS60_00755) 175667..176128 + 462 WP_034183865.1 hypothetical protein -
MRS60_RS00760 (MRS60_00760) 176125..176409 + 285 WP_175748245.1 type II toxin-antitoxin system RelE/ParE family toxin -
MRS60_RS00765 (MRS60_00765) 176660..176896 + 237 WP_243565079.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MRS60_RS00770 (MRS60_00770) 176896..177306 + 411 WP_034183868.1 type II toxin-antitoxin system VapC family toxin Toxin
MRS60_RS00775 (MRS60_00775) 177365..178753 - 1389 WP_217590123.1 L-serine ammonia-lyase -
MRS60_RS00780 (MRS60_00780) 178785..179921 - 1137 WP_243565080.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15294.43 Da        Isoelectric Point: 4.7249

>T239860 WP_034183868.1 NZ_CP094459:176896-177306 [Burkholderia pyrrocinia]
MPRYMLDTNMCIYLMRNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVAVCANPDRERLNLAALVEDIPVAPFDVAAAQA
YGPVRDATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLENWLNDSCP

Download         Length: 411 bp

>T239860 NZ_LS483365:c1512189-1511944 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9036.21 Da        Isoelectric Point: 5.1766

>AT239860 WP_243565079.1 NZ_CP094459:176660-176896 [Burkholderia pyrrocinia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTCVLEKFAKFGPDFMSEGRGDQEQAEREGL

Download         Length: 237 bp

>AT239860 NZ_LS483365:1511610-1511975 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References