Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 249469..250111 Replicon chromosome
Accession NZ_CP094455
Organism Bacillus sp. ZJS3

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag MQW34_RS01415 Protein ID WP_000635963.1
Coordinates 249761..250111 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag MQW34_RS01410 Protein ID WP_000004570.1
Coordinates 249469..249756 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQW34_RS01385 (MQW34_01385) 244785..245747 + 963 WP_243499068.1 UV DNA damage repair endonuclease UvsE -
MQW34_RS01390 (MQW34_01390) 245740..246312 - 573 WP_243499070.1 rhomboid family intramembrane serine protease -
MQW34_RS01395 (MQW34_01395) 246405..246764 + 360 WP_243499072.1 holo-ACP synthase -
MQW34_RS01400 (MQW34_01400) 246921..247871 + 951 WP_139365448.1 outer membrane lipoprotein carrier protein LolA -
MQW34_RS01405 (MQW34_01405) 247990..249159 + 1170 WP_078419335.1 alanine racemase -
MQW34_RS01410 (MQW34_01410) 249469..249756 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
MQW34_RS01415 (MQW34_01415) 249761..250111 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MQW34_RS01420 (MQW34_01420) 250179..252347 + 2169 WP_139365440.1 Tex family protein -
MQW34_RS01425 (MQW34_01425) 252406..252522 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
MQW34_RS01430 (MQW34_01430) 252718..253176 + 459 WP_243499074.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T239858 WP_000635963.1 NZ_CP094455:249761-250111 [Bacillus sp. ZJS3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T239858 NZ_LS483363:c2121337-2121068 [Streptococcus dysgalactiae subsp. equisimilis]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT239858 WP_000004570.1 NZ_CP094455:249469-249756 [Bacillus sp. ZJS3]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT239858 NZ_LS483363:c2121554-2121327 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCGCAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References