Detailed information of TA system TA239846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4957419..4957935
• Replicon: chromosome
• Accession: NZ_CP094451
• Organism: Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J2XDK6
• Locus tag: MRR30_RS24525
• Protein ID: WP_002886902.1
• Coordinates: 4957419..4957703 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MRR30_RS24530
• Protein ID: WP_002886901.1
• Coordinates: 4957693..4957935 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRR30_RS24500 (MRR30_24500)	4952903..4953166	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
MRR30_RS24505 (MRR30_24505)	4953296..4953469	+	174	WP_002886906.1	hypothetical protein	-
MRR30_RS24510 (MRR30_24510)	4953472..4954215	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MRR30_RS24515 (MRR30_24515)	4954572..4956710	+	2139	WP_002886904.1	anaerobic ribonucleoside-triphosphate reductase	-
MRR30_RS24520 (MRR30_24520)	4956951..4957415	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MRR30_RS24525 (MRR30_24525)	4957419..4957703	-	285	WP_002886902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MRR30_RS24530 (MRR30_24530)	4957693..4957935	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MRR30_RS24535 (MRR30_24535)	4958013..4959923	-	1911	WP_004152270.1	PRD domain-containing protein	-
MRR30_RS24540 (MRR30_24540)	4959946..4961100	-	1155	WP_002886900.1	lactonase family protein	-
MRR30_RS24545 (MRR30_24545)	4961166..4961906	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	sul1 / qacE / aadA2 / cmlA1 / aph(3'')-Ib / aph(6)-Id	-	4906793..5116063	209270

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.3787

>T239846 WP_002886902.1 NZ_CP094451:c4957703-4957419 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T239846 NZ_LS483357:1644182-1644517 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT239846 WP_002886901.1 NZ_CP094451:c4957935-4957693 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT239846 NZ_LS483357:1643905-1644192 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3GMH2

Antitoxin

• AlphaFold DB: A0A0H3GLP0