Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4852926..4853736 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag MRR30_RS24025 Protein ID WP_002887280.1
Coordinates 4852926..4853459 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag MRR30_RS24030 Protein ID WP_002887278.1
Coordinates 4853470..4853736 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS24020 (MRR30_24020) 4851757..4852878 + 1122 WP_002887282.1 cupin domain-containing protein -
MRR30_RS24025 (MRR30_24025) 4852926..4853459 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
MRR30_RS24030 (MRR30_24030) 4853470..4853736 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
MRR30_RS24035 (MRR30_24035) 4853839..4855272 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
MRR30_RS24040 (MRR30_24040) 4855262..4855945 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
MRR30_RS24045 (MRR30_24045) 4856117..4857502 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
MRR30_RS24050 (MRR30_24050) 4857520..4857864 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T239845 WP_002887280.1 NZ_CP094451:c4853459-4852926 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T239845 NZ_LS483356:1684031-1684366 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGGAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT239845 WP_002887278.1 NZ_CP094451:c4853736-4853470 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT239845 NZ_LS483356:1683754-1684041 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References