Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4240226..4240845 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MRR30_RS21080 Protein ID WP_002892050.1
Coordinates 4240627..4240845 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MRR30_RS21075 Protein ID WP_002892066.1
Coordinates 4240226..4240600 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS21065 (MRR30_21065) 4235378..4236571 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MRR30_RS21070 (MRR30_21070) 4236594..4239740 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
MRR30_RS21075 (MRR30_21075) 4240226..4240600 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MRR30_RS21080 (MRR30_21080) 4240627..4240845 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MRR30_RS21085 (MRR30_21085) 4241004..4241570 + 567 WP_002892030.1 maltose O-acetyltransferase -
MRR30_RS21090 (MRR30_21090) 4241542..4241682 - 141 WP_004147370.1 hypothetical protein -
MRR30_RS21095 (MRR30_21095) 4241703..4242173 + 471 WP_002892026.1 YlaC family protein -
MRR30_RS21100 (MRR30_21100) 4242148..4243599 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MRR30_RS21105 (MRR30_21105) 4243700..4244398 + 699 WP_002892021.1 GNAT family protein -
MRR30_RS21110 (MRR30_21110) 4244395..4244535 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MRR30_RS21115 (MRR30_21115) 4244535..4244798 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T239844 WP_002892050.1 NZ_CP094451:4240627-4240845 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T239844 NZ_LS483355:1514107-1514442 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT239844 WP_002892066.1 NZ_CP094451:4240226-4240600 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT239844 NZ_LS483355:1513830-1514117 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References