Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1240432..1241057 Replicon chromosome
Accession NC_012917
Organism Pectobacterium carotovorum subsp. carotovorum PC1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag PC1_RS05310 Protein ID WP_005976087.1
Coordinates 1240432..1240635 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag PC1_RS05315 Protein ID WP_005976089.1
Coordinates 1240689..1241057 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PC1_RS05285 1235874..1236212 + 339 WP_002208627.1 P-II family nitrogen regulator -
PC1_RS05290 1236250..1237536 + 1287 WP_015839357.1 ammonium transporter AmtB -
PC1_RS05295 1237689..1238552 - 864 WP_015839358.1 acyl-CoA thioesterase II -
PC1_RS05300 1238765..1239346 + 582 WP_015839359.1 YbaY family lipoprotein -
PC1_RS05305 1239366..1239686 - 321 WP_015839360.1 MGMT family protein -
PC1_RS05310 1240432..1240635 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
PC1_RS05315 1240689..1241057 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
PC1_RS05320 1241654..1241797 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
PC1_RS05325 1241815..1242063 - 249 WP_015839361.1 type B 50S ribosomal protein L31 -
PC1_RS05330 1242298..1245426 - 3129 WP_015839362.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T23984 WP_005976087.1 NC_012917:c1240635-1240432 [Pectobacterium carotovorum subsp. carotovorum PC1]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T23984 NC_012917:c1240635-1240432 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCACCGTCTGGCAGAACTGACGATGAACAAAC
TTTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT23984 WP_005976089.1 NC_012917:c1241057-1240689 [Pectobacterium carotovorum subsp. carotovorum PC1]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT23984 NC_012917:c1241057-1240689 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGCCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGGATTAATGATGCTGAACTGCGGCGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References