Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 914961..915615 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MRR30_RS04525 Protein ID WP_004144731.1
Coordinates 915208..915615 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MRR30_RS04520 Protein ID WP_002916312.1
Coordinates 914961..915227 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS04495 (MRR30_04495) 910117..911550 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MRR30_RS04500 (MRR30_04500) 911669..912397 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MRR30_RS04505 (MRR30_04505) 912447..912758 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MRR30_RS04510 (MRR30_04510) 912922..913581 + 660 WP_002916317.1 hemolysin III family protein -
MRR30_RS04515 (MRR30_04515) 913732..914715 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MRR30_RS04520 (MRR30_04520) 914961..915227 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MRR30_RS04525 (MRR30_04525) 915208..915615 + 408 WP_004144731.1 protein YgfX Toxin
MRR30_RS04530 (MRR30_04530) 915622..916143 - 522 WP_002916308.1 flavodoxin FldB -
MRR30_RS04535 (MRR30_04535) 916244..917140 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MRR30_RS04540 (MRR30_04540) 917163..917876 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MRR30_RS04545 (MRR30_04545) 917882..919615 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T239834 WP_004144731.1 NZ_CP094451:915208-915615 [Klebsiella pneumoniae subsp. rhinoscleromatis]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T239834 NZ_LS483350:c2119536-2119174 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT239834 WP_002916312.1 NZ_CP094451:914961-915227 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239834 NZ_LS483350:c2119703-2119533 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References