Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1677226..1678862 Replicon chromosome
Accession NZ_CP094445
Organism Acinetobacter junii strain A2-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MRY16_RS07910 Protein ID WP_243482421.1
Coordinates 1677226..1678557 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MRY16_RS07915 Protein ID WP_004954417.1
Coordinates 1678554..1678862 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY16_RS07885 (MRY16_07885) 1672623..1673618 + 996 WP_212638270.1 DUF1852 domain-containing protein -
MRY16_RS07890 (MRY16_07890) 1673642..1674670 + 1029 WP_243482410.1 methionine synthase -
MRY16_RS07895 (MRY16_07895) 1674857..1675351 + 495 WP_130575626.1 flavin reductase -
MRY16_RS07900 (MRY16_07900) 1675393..1676190 + 798 WP_039907982.1 sulfite exporter TauE/SafE family protein -
MRY16_RS07905 (MRY16_07905) 1676250..1676948 - 699 WP_243482412.1 DUF1826 domain-containing protein -
MRY16_RS07910 (MRY16_07910) 1677226..1678557 + 1332 WP_243482421.1 HipA domain-containing protein Toxin
MRY16_RS07915 (MRY16_07915) 1678554..1678862 + 309 WP_004954417.1 helix-turn-helix transcriptional regulator Antitoxin
MRY16_RS07920 (MRY16_07920) 1678932..1679183 - 252 WP_151959006.1 VF530 family protein -
MRY16_RS07925 (MRY16_07925) 1679628..1680842 + 1215 WP_243482424.1 tyrosine-type recombinase/integrase -
MRY16_RS07930 (MRY16_07930) 1680829..1682349 + 1521 WP_243482426.1 site-specific integrase -
MRY16_RS07935 (MRY16_07935) 1682352..1683845 + 1494 WP_243482428.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50714.47 Da        Isoelectric Point: 5.1234

>T239829 WP_243482421.1 NZ_CP094445:1677226-1678557 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYDLEYAIHNLDKRDEHACSLSLPIQILIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSHSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETIEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRHGLESVYSVLNKASGSHLNHFEVIENLCNLLISIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWEQIAQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T239829 NZ_LS483350:c837880-837692 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11692.65 Da        Isoelectric Point: 9.9970

>AT239829 WP_004954417.1 NZ_CP094445:1678554-1678862 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT239829 NZ_LS483350:c838169-837909 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References