Detailed information of TA system TA239828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2870669..2871198
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX2
• Locus tag: MTP23_RS14345
• Protein ID: WP_001103933.1
• Coordinates: 2870881..2871198 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A6B0BJC0
• Locus tag: MTP23_RS14340
• Protein ID: WP_001058487.1
• Coordinates: 2870669..2870878 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS14305 (2865900)	2865900..2866184	+	285	WP_000917289.1	co-chaperone GroES	-
MTP23_RS14310 (2866260)	2866260..2867876	+	1617	WP_000240642.1	chaperonin GroEL	-
MTP23_RS14315 (2867945)	2867945..2869117	-	1173	WP_000179353.1	tyrosine-type recombinase/integrase	-
MTP23_RS14320 (2869131)	2869131..2869853	-	723	WP_000672427.1	helix-turn-helix transcriptional regulator	-
MTP23_RS14325 (2870006)	2870006..2870212	+	207	WP_000794657.1	helix-turn-helix transcriptional regulator	-
MTP23_RS14330 (2870216)	2870216..2870533	+	318	WP_000481968.1	helix-turn-helix domain-containing protein	-
MTP23_RS14335 (2870530)	2870530..2870676	+	147	WP_000708434.1	hypothetical protein	-
MTP23_RS14340 (2870669)	2870669..2870878	+	210	WP_001058487.1	hypothetical protein	Antitoxin
MTP23_RS14345 (2870881)	2870881..2871198	+	318	WP_001103933.1	DUF1474 family protein	Toxin
MTP23_RS14350 (2871265)	2871265..2872134	+	870	WP_001002699.1	primase alpha helix C-terminal domain-containing protein	-
MTP23_RS14355 (2872151)	2872151..2873620	+	1470	WP_001838755.1	virulence-associated E family protein	-
MTP23_RS14360 (2873906)	2873906..2874268	+	363	WP_001039169.1	hypothetical protein	-
MTP23_RS14365 (2874270)	2874270..2874554	+	285	WP_000998179.1	hypothetical protein	-
MTP23_RS14370 (2874551)	2874551..2875192	+	642	WP_001019811.1	hypothetical protein	-
MTP23_RS14375 (2875728)	2875728..2876069	+	342	WP_000443639.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb	2865900..2907944	42044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12511.13 Da
• Isoelectric Point: 4.6364

>T239828 WP_001103933.1 NZ_CP094443:2870881-2871198 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Nucleotide

• Length: 318 bp

>T239828 NZ_LS483349:741130-741321 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8228.24 Da
• Isoelectric Point: 4.1682

>AT239828 WP_001058487.1 NZ_CP094443:2870669-2870878 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT239828 NZ_LS483349:741339-741716 [Streptococcus mutans]
ATGTTAAAATCATATCCTGCAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Structures

Toxin

• AlphaFold DB: K7ZRX2

Antitoxin

• AlphaFold DB: A0A6B0BJC0