Detailed information of TA system TA239827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2818774..2819303
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MTP23_RS14075
• Protein ID: WP_000621175.1
• Coordinates: 2818941..2819303 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MTP23_RS14070
• Protein ID: WP_000948331.1
• Coordinates: 2818774..2818944 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS14040 (2813811)	2813811..2814371	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
MTP23_RS14045 (2814579)	2814579..2815058	+	480	WP_001287087.1	hypothetical protein	-
MTP23_RS14050 (2815051)	2815051..2816634	+	1584	WP_001294626.1	PH domain-containing protein	-
MTP23_RS14055 (2816621)	2816621..2817112	+	492	WP_001205912.1	PH domain-containing protein	-
MTP23_RS14060 (2817116)	2817116..2817475	+	360	WP_000581197.1	holo-ACP synthase	-
MTP23_RS14065 (2817541)	2817541..2818689	+	1149	WP_001281154.1	alanine racemase	-
MTP23_RS14070 (2818774)	2818774..2818944	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MTP23_RS14075 (2818941)	2818941..2819303	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MTP23_RS14080 (2819652)	2819652..2820653	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MTP23_RS14085 (2820772)	2820772..2821098	+	327	WP_001052491.1	anti-sigma factor antagonist	-
MTP23_RS14090 (2821100)	2821100..2821579	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
MTP23_RS14095 (2821554)	2821554..2822324	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T239827 WP_000621175.1 NZ_CP094443:2818941-2819303 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T239827 NZ_LS483349:200685-201017 [Streptococcus mutans]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT239827 WP_000948331.1 NZ_CP094443:2818774-2818944 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT239827 NZ_LS483349:200446-200691 [Streptococcus mutans]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1