Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2797529..2798043 Replicon chromosome
Accession NZ_CP094443
Organism Staphylococcus aureus strain N10CSA27

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MTP23_RS13975 Protein ID WP_000581792.1
Coordinates 2797834..2798043 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MTP23_RS13970 Protein ID WP_000138932.1
Coordinates 2797529..2797822 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP23_RS13950 (2792692) 2792692..2793333 + 642 WP_000483153.1 thiamine phosphate synthase -
MTP23_RS13955 (2793419) 2793419..2794291 + 873 WP_000725802.1 membrane protein insertase YidC -
MTP23_RS13960 (2795204) 2795204..2795851 - 648 WP_001187630.1 HD domain-containing protein -
MTP23_RS13965 (2795879) 2795879..2797363 - 1485 WP_000571549.1 cardiolipin synthase -
MTP23_RS13970 (2797529) 2797529..2797822 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MTP23_RS13975 (2797834) 2797834..2798043 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MTP23_RS13980 (2798171) 2798171..2798308 + 138 WP_000828354.1 Lmo0850 family protein -
MTP23_RS13985 (2798572) 2798572..2799774 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MTP23_RS13990 (2800092) 2800092..2801162 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MTP23_RS13995 (2801177) 2801177..2802535 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T239826 WP_000581792.1 NZ_CP094443:2797834-2798043 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T239826 NZ_LS483349:c188141-187863 [Streptococcus mutans]
ATGTACCAAGTCAAGTTCACCTCTGCTTTTAAAAAGAGCTACAAACGGATTAAAAAGCGAGGCTTAGAGATGACACTCTT
AGATGAAGTGATTGAAAAACTCCGCCTAGGACAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGCCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGATGATATTTTGACATTGACTTTA
GCTGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT239826 WP_000138932.1 NZ_CP094443:2797529-2797822 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT239826 NZ_LS483349:c188414-188142 [Streptococcus mutans]
ATGGCAACTGTTCCAACGCAAATTCGGATTGATGAAACTGTCAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCGGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTCCCCA
ATTATAGCCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTCGCTTCTTATGGCAAT
CTAGCAGATTTAAAGAAGGCTCTGGAAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References