Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
| Location | 2423925..2424448 | Replicon | chromosome |
| Accession | NZ_CP094443 | ||
| Organism | Staphylococcus aureus strain N10CSA27 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A3A5LQI3 |
| Locus tag | MTP23_RS12025 | Protein ID | WP_000074049.1 |
| Coordinates | 2424182..2424448 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | W8TQT5 |
| Locus tag | MTP23_RS12020 | Protein ID | WP_000587616.1 |
| Coordinates | 2423925..2424182 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTP23_RS12005 (2420422) | 2420422..2421171 | - | 750 | WP_000072461.1 | CPBP family lipoprotein N-acylation protein LnsB | - |
| MTP23_RS12010 (2421366) | 2421366..2422943 | + | 1578 | WP_000143494.1 | FMN-binding glutamate synthase family protein | - |
| MTP23_RS12015 (2423111) | 2423111..2423566 | - | 456 | WP_000732076.1 | DUF1307 domain-containing protein | - |
| MTP23_RS12020 (2423925) | 2423925..2424182 | + | 258 | WP_000587616.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MTP23_RS12025 (2424182) | 2424182..2424448 | + | 267 | WP_000074049.1 | Txe/YoeB family addiction module toxin | Toxin |
| MTP23_RS12030 (2424803) | 2424803..2425879 | + | 1077 | WP_001076673.1 | M42 family metallopeptidase | - |
| MTP23_RS12035 (2426127) | 2426127..2426789 | + | 663 | WP_000923526.1 | ATP-binding cassette domain-containing protein | - |
| MTP23_RS12040 (2426782) | 2426782..2427558 | + | 777 | WP_000072149.1 | iron export ABC transporter permease subunit FetB | - |
| MTP23_RS12045 (2427954) | 2427954..2429141 | + | 1188 | WP_000026189.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10676.24 Da Isoelectric Point: 10.1597
>T239818 WP_000074049.1 NZ_CP094443:2424182-2424448 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
Download Length: 267 bp
>T239818 NZ_LS483343:75382-76155 [Streptococcus ferus]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAAAC
TATTCCGGACCAACCGAAAGCTATCTTACTTGGTGGACAAAGCGGAGCGGGTAAGACAACGATTCATCGAATTAAACAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTATCGTTCTCAACACCCCAATTACCTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGTATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGTCATCGATCCTAATCAGGCCAGGGCAACATCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGAGAA
CTTGAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAGAGAGATCGAACTTGTATCTACGATTCTG
AAACCGATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATGCCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGATGGGGCAAGAGCGGTTAAGAGAGATTTCAGTAATAAAAGAAAATTTGTAG
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAAAC
TATTCCGGACCAACCGAAAGCTATCTTACTTGGTGGACAAAGCGGAGCGGGTAAGACAACGATTCATCGAATTAAACAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTATCGTTCTCAACACCCCAATTACCTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGTATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCTA
AAGGTTACCAAGTTTCTTTAGCTGTAATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGTCATCGATCCTAATCAGGCCAGGGCAACATCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGAGAA
CTTGAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAGAGAGATCGAACTTGTATCTACGATTCTG
AAACCGATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATGCCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGATGGGGCAAGAGCGGTTAAGAGAGATTTCAGTAATAAAAGAAAATTTGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9774.73 Da Isoelectric Point: 4.1353
>AT239818 WP_000587616.1 NZ_CP094443:2423925-2424182 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
Download Length: 258 bp
>AT239818 NZ_LS483343:74906-75382 [Streptococcus ferus]
ATGATTGGAGACAATATAAAATCTTTACGACACAAACATCATTTGACGCAGCCCGAATTTGCAGAAATGGTTGGGATTTC
CCGCAATAGCCTGAGTCGGTATGAAAATGGAACCAGCACCGTTTCAACAGAACTGATCGATCGCATTTGCCAAGAATTTA
ACATTTCTTATGTCGATATTGTAGGGGAGGACAAAATGCTAACACCCGTTGAAGATTACCAATTGACCTTAAAAGTAGAA
GTCATTAAAGAACGTGGGGCAGCCATTTTATCCCAGCTCTATCGTTATCAGGATAGTCAGGATATTGCTTTTGATGATGA
AGCCAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTATCTTGTCGATACTTTCGATG
AAATCGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA
ATGATTGGAGACAATATAAAATCTTTACGACACAAACATCATTTGACGCAGCCCGAATTTGCAGAAATGGTTGGGATTTC
CCGCAATAGCCTGAGTCGGTATGAAAATGGAACCAGCACCGTTTCAACAGAACTGATCGATCGCATTTGCCAAGAATTTA
ACATTTCTTATGTCGATATTGTAGGGGAGGACAAAATGCTAACACCCGTTGAAGATTACCAATTGACCTTAAAAGTAGAA
GTCATTAAAGAACGTGGGGCAGCCATTTTATCCCAGCTCTATCGTTATCAGGATAGTCAGGATATTGCTTTTGATGATGA
AGCCAATCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTATCTTGTCGATACTTTCGATG
AAATCGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3A5LQI3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7V6W | |
| PDB | 7V5Z | |
| PDB | 7V5Y | |
| AlphaFold DB | W8TQT5 |